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	<title>JustTheScience &#187; short-term metabolic effects</title>
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	<description>We Do The Research</description>
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		<title>Does it matter when you eat?</title>
		<link>http://justthescience.com/archives/681</link>
		<comments>http://justthescience.com/archives/681#comments</comments>
		<pubDate>Fri, 13 Nov 2009 06:45:17 +0000</pubDate>
		<dc:creator></dc:creator>
				<category><![CDATA[Personal Health]]></category>
		<category><![CDATA[basal metabolic rate]]></category>
		<category><![CDATA[bedtime]]></category>
		<category><![CDATA[breakfast]]></category>
		<category><![CDATA[eating]]></category>
		<category><![CDATA[fat]]></category>
		<category><![CDATA[feeding frequency]]></category>
		<category><![CDATA[feeding timing]]></category>
		<category><![CDATA[fewer concentrated meals]]></category>
		<category><![CDATA[late night eating]]></category>
		<category><![CDATA[metabolic]]></category>
		<category><![CDATA[obesity]]></category>
		<category><![CDATA[overeating]]></category>
		<category><![CDATA[overindulge]]></category>
		<category><![CDATA[prepared portion of food]]></category>
		<category><![CDATA[short-term metabolic effects]]></category>
		<category><![CDATA[sleeping]]></category>
		<category><![CDATA[smaller meals]]></category>
		<category><![CDATA[Theories]]></category>

		<guid isPermaLink="false">http://justthescience.com/?p=681</guid>
		<description><![CDATA[There have been many different theories regarding when and how often an individual should eat, among them: including vs. skipping breakfast, not eating anything before bedtime, and eating several smaller meals vs. fewer concentrated meals.  In this article, we intend to examine whether or not feeding timing and frequency is relevant to metabolism, and/or satiation. [...]]]></description>
			<content:encoded><![CDATA[<p>There have been many different theories regarding when and how often an individual should eat, among them: including vs. skipping breakfast, not eating anything before bedtime, and eating several smaller meals vs. fewer concentrated meals.  In this article, we intend to examine whether or not feeding timing and frequency is relevant to metabolism, and/or satiation.</p>
<p>Including breakfast in one’s day has been shown to have myriad effects.  De Castro (2004) found those that skip breakfast are more likely to overeat later. <sup><a href="http://justthescience.com/archives/681#footnote_0_681" id="identifier_0_681" class="footnote-link footnote-identifier-link" title="The time of day of food intake influences overall intake in humans">1</a></sup>   Additionally, Schlundt <em>et al</em> (1992) and Stubbs <em>et al</em> (1996) found those that eat breakfast eat less fat throughout the day and are less prone to impulsive eating of familiar foods. <sup><a href="http://justthescience.com/archives/681#footnote_1_681" id="identifier_1_681" class="footnote-link footnote-identifier-link" title="The role of breakfast in the treatment of obesity: a randomized clinical trial">2</a></sup><sup><a href="http://justthescience.com/archives/681#footnote_2_681" id="identifier_2_681" class="footnote-link footnote-identifier-link" title="Breakfasts high in protein, fat or carbohydrate: effect on within-day appetite and energy balance">3</a></sup> However, multiple studies have found that feeding frequency and timing does not have an effect on metabolic performance (Wilhelmine <em>et al</em> 1998) (Dallosso <em>et al 1982) (</em> Verboeket van de Venne and Westerterp 1998) (Wolfram <em>et al</em> 1987). <sup><a href="http://justthescience.com/archives/681#footnote_3_681" id="identifier_3_681" class="footnote-link footnote-identifier-link" title="Effect of the pattern of food intake on human energy metabolism">4</a></sup> <sup><a href="http://justthescience.com/archives/681#footnote_4_681" id="identifier_4_681" class="footnote-link footnote-identifier-link" title="Feeding frequency and energy balance in adult males">5</a></sup> <sup><a href="http://justthescience.com/archives/681#footnote_5_681" id="identifier_5_681" class="footnote-link footnote-identifier-link" title="Frequency of feeding, weight reduction and energy metabolism">6</a></sup> <sup><a href="http://justthescience.com/archives/681#footnote_6_681" id="identifier_6_681" class="footnote-link footnote-identifier-link" title="Thermogenesis in humans after varying meal time frequency">7</a></sup> In addition, Goldberg <em>et al</em> (1998) found that one’s metabolic rate while sleeping is roughly concurrent with one’s basal metabolic rate (BMR), which in combination with results from the previously mentioned studies suggests that there are no adverse metabolic effects from eating before sleeping.<sup><a href="http://justthescience.com/archives/681#footnote_7_681" id="identifier_7_681" class="footnote-link footnote-identifier-link" title="Overnight and basal metabolic rates in men and women">8</a></sup>  However, it is important if you are partaking in late night eating that you eat a prepared portion of food, as it’s been demonstrated that it&#8217;s common for individuals to overindulge late (Waller <em>et al</em> 2004). <sup><a href="http://justthescience.com/archives/681#footnote_8_681" id="identifier_8_681" class="footnote-link footnote-identifier-link" title="Evening Ready-to-Eat Cereal Consumption Contributes to Weight Management">9</a></sup></p>
<p>Eating more frequent smaller meals has been shown to decrease future hunger more effectively than eating few highly concentrated meals (Speechly and Buffenstein 1999).  Johnstone <em>et al</em> (2000) found similar results in their study, and also determined that the nutritional composition of these smaller meals (i.e. high in protein, fat, or carbohydrates) did not affect later decreased hunger, provided they contained a similar caloric composition<sup><a href="http://justthescience.com/archives/681#footnote_9_681" id="identifier_9_681" class="footnote-link footnote-identifier-link" title="Greater Appetite Control Associated with an Increased Frequency of Eating in Lean Males">10</a></sup> <sup><a href="http://justthescience.com/archives/681#footnote_10_681" id="identifier_10_681" class="footnote-link footnote-identifier-link" title="Altering the temporal distribution of energy intake with isoenergetically dense foods given as snacks does not affect total daily energy intake in normal-weight men">11</a></sup></p>
<ol class="footnotes"><li id="footnote_0_681" class="footnote"><a href="http://jn.nutrition.org/cgi/content/full/134/1/104">The time of day of food intake influences overall intake in humans</a></li><li id="footnote_1_681" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/55/3/645">The role of breakfast in the treatment of obesity: a randomized clinical trial</a></li><li id="footnote_2_681" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/8862476">Breakfasts high in protein, fat or carbohydrate: effect on within-day appetite and energy balance</a></li><li id="footnote_3_681" class="footnote"><a href="http://journals.cambridge.org/action/displayAbstract?fromPage=online&amp;aid=873508">Effect of the pattern of food intake on human energy metabolism</a></li><li id="footnote_4_681" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/7076516">Feeding frequency and energy balance in adult males</a></li><li id="footnote_5_681" class="footnote"><a href="http://grande.nal.usda.gov/ibids/index.php?mode2=detail&amp;origin=ibids_references&amp;therow=81268">Frequency of feeding, weight reduction and energy metabolism</a></li><li id="footnote_6_681" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/3592618">Thermogenesis in humans after varying meal time frequency</a></li><li id="footnote_7_681" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/3378547">Overnight and basal metabolic rates in men and women</a></li><li id="footnote_8_681" class="footnote"><a href="http://www.jacn.org/cgi/content/abstract/23/4/316">Evening Ready-to-Eat Cereal Consumption Contributes to Weight Management</a></li><li id="footnote_9_681" class="footnote"><a href="http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6WB2-45GW6BS-2&amp;_user=10&amp;_rdoc=1&amp;_fmt=&amp;_orig=search&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_searchStrId=1085330660&amp;_rerunOrigin=scholar.google&amp;_acct=C000050221&amp;_version=1&amp;_urlVersion=0&amp;_userid=10&amp;md5=e9cf7c64a27f1bcda0da8687867f437f">Greater Appetite Control Associated with an Increased Frequency of Eating in Lean Males</a></li><li id="footnote_10_681" class="footnote"><a href="http://journals.cambridge.org/action/displayAbstract?fromPage=online&amp;aid=878712">Altering the temporal distribution of energy intake with isoenergetically dense foods given as snacks does not affect total daily energy intake in normal-weight men</a></li></ol>]]></content:encoded>
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		<item>
		<title>High Fructose Corn Syrup; good or bad?</title>
		<link>http://justthescience.com/archives/563</link>
		<comments>http://justthescience.com/archives/563#comments</comments>
		<pubDate>Thu, 22 Oct 2009 16:14:14 +0000</pubDate>
		<dc:creator></dc:creator>
				<category><![CDATA[Personal Health]]></category>
		<category><![CDATA[caloric sweeteners]]></category>
		<category><![CDATA[chronic diseases]]></category>
		<category><![CDATA[Coke]]></category>
		<category><![CDATA[diabetes]]></category>
		<category><![CDATA[dietary allowance]]></category>
		<category><![CDATA[ectopic lipid]]></category>
		<category><![CDATA[food]]></category>
		<category><![CDATA[fructose]]></category>
		<category><![CDATA[fruit]]></category>
		<category><![CDATA[HFCS]]></category>
		<category><![CDATA[high fructose corn syrup]]></category>
		<category><![CDATA[insulin]]></category>
		<category><![CDATA[insulin resistance]]></category>
		<category><![CDATA[metabolic]]></category>
		<category><![CDATA[milk]]></category>
		<category><![CDATA[obesity]]></category>
		<category><![CDATA[satiety]]></category>
		<category><![CDATA[short-term metabolic effects]]></category>
		<category><![CDATA[sucrose]]></category>
		<category><![CDATA[sweeteners]]></category>
		<category><![CDATA[westernization]]></category>

		<guid isPermaLink="false">http://justthescience.com/?p=563</guid>
		<description><![CDATA[As levels of diabetes, obesity, and other dietary issues increase (diabetes alone has increased 763% from 1935 to 1996 in the united states (Gross et al 2004)) studies have been conducted to investigate whether the 1,000% rise in the use of High Fructose Corn Syrup (HFCS) from 1967 to 2000 in the American food industry [...]]]></description>
			<content:encoded><![CDATA[<p>As levels of diabetes, obesity, and other dietary issues increase (diabetes alone has increased 763% from 1935 to 1996 in the united states (Gross <em>et al</em> 2004)) studies have been conducted to investigate whether the 1,000% rise in the use of High Fructose Corn Syrup (HFCS) from 1967 to 2000 in the American food industry is a major contributor (Bray <em>et al</em> 2004).<sup><a href="http://justthescience.com/archives/563#footnote_0_563" id="identifier_0_563" class="footnote-link footnote-identifier-link" title="Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity">1</a></sup>  <sup><a href="http://justthescience.com/archives/563#footnote_1_563" id="identifier_1_563" class="footnote-link footnote-identifier-link" title="Fructose, insulin resistance, and metabolic dyslipidemia">2</a></sup> In this article, we will examine whether or not HFCS is truly a factor in this significant increase.</p>
<p>Early studies found that there were possible clinical explanations for metabolic differences derived from HFCS ingestion and other sweeteners; primarily that it did not trigger insulin creation and thereby was thought to not trigger satiety signals (Reiser <em>et al</em> 1989) (Elliott <em>et al</em> 2002) (Bray <em>et al</em> 2004) (Teff <em>et al</em> 2004) .<sup><a href="http://justthescience.com/archives/563#footnote_2_563" id="identifier_2_563" class="footnote-link footnote-identifier-link" title="Fructose, weight gain, and the insulin resistance syndrome">3</a></sup> <sup><a href="http://justthescience.com/archives/563#footnote_3_563" id="identifier_3_563" class="footnote-link footnote-identifier-link" title="Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity">4</a></sup> <sup><a href="http://justthescience.com/archives/563#footnote_4_563" id="identifier_4_563" class="footnote-link footnote-identifier-link" title="Dietary Fructose Reduces Circulating Insulin and Leptin, Attenuates Postprandial Suppression of Ghrelin, and Increases Triglycerides in Women">5</a></sup> <sup><a href="http://justthescience.com/archives/563#footnote_5_563" id="identifier_5_563" class="footnote-link footnote-identifier-link" title="Day-long glucose, insulin, and fructose responses of hyperinsulinemic and nonhyperinsulinemic men adapted to diets containing either fructose or high-amylose cornstarch">6</a></sup>  However, more recent studies have found no difference in resulting satiety in men or women resulting from HFCS, sucrose, or milk, (Soenen and Westerterp-Plantenga 2007) (Melanson <em>et al 2008)</em> (Akhavan and Anderson 2007),<sup><a href="http://justthescience.com/archives/563#footnote_6_563" id="identifier_6_563" class="footnote-link footnote-identifier-link" title="No differences in satiety or energy intake after high-fructose corn syrup, sucrose, or milk preloads">7</a></sup> <sup><a href="http://justthescience.com/archives/563#footnote_7_563" id="identifier_7_563" class="footnote-link footnote-identifier-link" title="High-fructose corn syrup, energy intake, and appetite regulation">8</a></sup> <sup><a href="http://justthescience.com/archives/563#footnote_8_563" id="identifier_8_563" class="footnote-link footnote-identifier-link" title="Effects of glucose-to-fructose ratios in solutions on subjective satiety, food intake, and satiety hormones in young men">9</a></sup> and that HFCS yields similar metabolic responses to other caloric sweeteners. (Angelopoulos <em>et al</em> 2009),<sup><a href="http://justthescience.com/archives/563#footnote_9_563" id="identifier_9_563" class="footnote-link footnote-identifier-link" title="The Effect of High-Fructose Corn Syrup Consumption on Triglycerides and Uric Acid">10</a></sup> Stanhope <em>et al</em> 2008 and Melanson  <em>et al</em> 2007 determined that sucrose and HFCS do not have significantly different short-term metabolic effects,<sup><a href="http://justthescience.com/archives/563#footnote_10_563" id="identifier_10_563" class="footnote-link footnote-identifier-link" title="Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals">11</a></sup> <sup><a href="http://justthescience.com/archives/563#footnote_11_563" id="identifier_11_563" class="footnote-link footnote-identifier-link" title="Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women">12</a></sup> and moderate levels (~1.5 grams of fructose per kilogram of body mass) of HFCS intake  does not cause ectopic lipid deposition or insulin resistance in healthy humans (Le <em>et al</em> 2006).<sup><a href="http://justthescience.com/archives/563#footnote_12_563" id="identifier_12_563" class="footnote-link footnote-identifier-link" title="A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans">13</a></sup></p>
<p>Although HFCS is not itself responsible for the increase in dietary and metabolic disorders, other studies have demonstrated that increasing levels of excess energy consumption in general is a cause (Gross <em>et al</em> 2004).<sup><a href="http://justthescience.com/archives/563#footnote_13_563" id="identifier_13_563" class="footnote-link footnote-identifier-link" title="Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment">14</a></sup>  For thousands of years humans consumed fructose amounting to 16–20 grams per day, largely from fresh fruits (Gross <em>et al</em> 2004). <sup><a href="http://justthescience.com/archives/563#footnote_14_563" id="identifier_14_563" class="footnote-link footnote-identifier-link" title="Fructose, insulin resistance, and metabolic dyslipidemia">15</a></sup> Westernization of diets has resulted in significant increases in food with added fructose, leading to typical daily consumptions amounting to 85–100 grams of fructose per day (Gross <em>et al</em> 2004). <sup><a href="http://justthescience.com/archives/563#footnote_15_563" id="identifier_15_563" class="footnote-link footnote-identifier-link" title="Fructose, insulin resistance, and metabolic dyslipidemia">16</a></sup>  For example, a 12 ounce Coke contains 39 grams of fructose and the USDA Recommended Daily Allowance allots for 32 grams of carbohydrates in a 2,000 calorie diet.<sup><a href="http://justthescience.com/archives/563#footnote_16_563" id="identifier_16_563" class="footnote-link footnote-identifier-link" title="Carbohydrates">17</a></sup>  A single 12 ounce Coke therefore contains significantly more than an individual&#8217;s entire excess dietary energy allowance for a day.  Raben <em>et al </em>2002 found that people have a very difficult time compensating for increased levels of calories associated with increased sugar intake by lowering caloric intake elsewhere.<sup><a href="http://justthescience.com/archives/563#footnote_17_563" id="identifier_17_563" class="footnote-link footnote-identifier-link" title="Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects">18</a></sup>  While moderate ingestion of HFCS will not specifically cause harm to oneself, it is advisable to monitor and limit consumption as much as possible.</p>
<ol class="footnotes"><li id="footnote_0_563" class="footnote"><a href="http://www.ajcn.cnfindpark.cn/cgi/content/abstract/79/4/537">Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity</a></li><li id="footnote_1_563" class="footnote"><a href="http://www.nutritionandmetabolism.com/content/2/1/5" target="_blank">Fructose, insulin resistance, and metabolic dyslipidemia</a></li><li id="footnote_2_563" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/76/5/911">Fructose, weight gain, and the insulin resistance syndrome</a></li><li id="footnote_3_563" class="footnote"><a href="http://www.ajcn.cnfindpark.cn/cgi/content/abstract/79/4/537">Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity</a></li><li id="footnote_4_563" class="footnote"><a href="http://jcem.endojournals.org/cgi/content/abstract/89/6/2963">Dietary Fructose Reduces Circulating Insulin and Leptin, Attenuates Postprandial Suppression of Ghrelin, and Increases Triglycerides in Women</a></li><li id="footnote_5_563" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/50/5/1008">Day-long glucose, insulin, and fructose responses of hyperinsulinemic and nonhyperinsulinemic men adapted to diets containing either fructose or high-amylose cornstarch</a></li><li id="footnote_6_563" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/86/6/1586">No differences in satiety or energy intake after high-fructose corn syrup, sucrose, or milk preloads</a></li><li id="footnote_7_563" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/88/6/1738S?ijkey=51a6eb2a2a2308a265762245d4dc6f538a555c36&amp;keytype2=tf_ipsecsha">High-fructose corn syrup, energy intake, and appetite regulation</a></li><li id="footnote_8_563" class="footnote"><a href="http://www.ajcn.cnfindpark.cn/cgi/content/abstract/86/5/1354">Effects of glucose-to-fructose ratios in solutions on subjective satiety, food intake, and satiety hormones in young men</a></li><li id="footnote_9_563" class="footnote"><a href="http://jn.nutrition.org/cgi/content/abstract/139/6/1242S">The Effect of High-Fructose Corn Syrup Consumption on Triglycerides and Uric Acid</a></li><li id="footnote_10_563" class="footnote"><a href="http://ajcn.cnfindpark.cn/cgi/content/abstract/87/5/1194">Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals</a></li><li id="footnote_11_563" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/17234503">Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women</a></li><li id="footnote_12_563" class="footnote"><a href="http://cat.inist.fr/?aModele=afficheN&amp;cpsidt=18373945">A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans</a></li><li id="footnote_13_563" class="footnote"><a href="http://www.ajcn.org/cgi/content/full/79/5/774?ijkey=cJSxz0rjkfs9s&amp;keytype=ref&amp;siteid=ajcn">Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment</a></li><li id="footnote_14_563" class="footnote"><a href="http://www.nutritionandmetabolism.com/content/2/1/5" target="_blank">Fructose, insulin resistance, and metabolic dyslipidemia</a></li><li id="footnote_15_563" class="footnote"><a href="http://www.nutritionandmetabolism.com/content/2/1/5#B7">Fructose, insulin resistance, and metabolic dyslipidemia</a></li><li id="footnote_16_563" class="footnote"><a href="http://www.health.gov/dietaryguidelines/dga2005/document/html/chapter7.htm" target="_blank">Carbohydrates</a></li><li id="footnote_17_563" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/12324283?dopt=Abstract&amp;holding=f1000,f1000m,isrctn">Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects</a></li></ol>]]></content:encoded>
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