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	<title>JustTheScience &#187; Personal Health</title>
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	<description>We Do The Research</description>
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		<title>What are the health effects of consuming food containing MSG?</title>
		<link>http://justthescience.com/archives/785</link>
		<comments>http://justthescience.com/archives/785#comments</comments>
		<pubDate>Tue, 15 Jun 2010 22:52:40 +0000</pubDate>
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				<category><![CDATA[Personal Health]]></category>

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		<description><![CDATA[Originally synthesized from kelp by Japanese researchers in 1908, Monosodium Glutamate (MSG) is now a major component of the food industry with 2009 global production levels estimated at 2 million tons (Sano 2009). 1  The glutamate class of acids including MSG activates taste sensors that are responsible for the savory flavor, also called “umami,” which is [...]]]></description>
			<content:encoded><![CDATA[<p>Originally synthesized from kelp by Japanese researchers in 1908, Monosodium Glutamate (MSG) is now a major component of the food industry with 2009 global production levels estimated at 2 million tons (Sano 2009). <sup><a href="http://justthescience.com/archives/785#footnote_0_785" id="identifier_0_785" class="footnote-link footnote-identifier-link" title="History of glutamate production">1</a></sup>  The glutamate class of acids including MSG activates taste sensors that are responsible for the savory flavor, also called “umami,” which is considered to be a basic taste along with sweet, sour, salty, and bitter (Rolls 2009) (Kurihara 2009). <sup><a href="http://justthescience.com/archives/785#footnote_1_785" id="identifier_1_785" class="footnote-link footnote-identifier-link" title="Functional neuroimaging of umami taste: what makes umami pleasant?">2</a></sup> <sup><a href="http://justthescience.com/archives/785#footnote_2_785" id="identifier_2_785" class="footnote-link footnote-identifier-link" title="Glutamate: from discovery as a food flavor to role as a basic taste (umami)">3</a></sup>  Americanized Chinese food is widely known for its MSG content, particularly due to the 1960&#8242;s MSG related phenomenon dubbed &#8220;Chinese Restaurant Syndrome (CRS).&#8221;  Afflicted individuals with CRS exhibited symptoms including burning sensations, and facial and chest pain, following eating at Chinese restaurants that used MSG as a food additive (Schaumburg <em>et al</em> 1969). <sup><a href="http://justthescience.com/archives/785#footnote_3_785" id="identifier_3_785" class="footnote-link footnote-identifier-link" title="Monosodium L-Glutamate: Its Pharmacology and Role in the Chinese Restaurant Syndrome">4</a></sup>  Media coverage caused hyper-awareness of the syndrome, as is evident by a 1979 survey by Kerr <em>et al</em> (1979), in which 43% of respondents stated that they had suffered from CRS, despite only 2% of respondents reporting ever having symptoms matching those widely attributed to CRS.<sup><a href="http://justthescience.com/archives/785#footnote_4_785" id="identifier_4_785" class="footnote-link footnote-identifier-link" title="Prevalence of the &amp;#8220;Chinese restaurant syndrome&amp;#8221;">5</a></sup></p>
<p>Although public awareness of the symptoms of Chinese Restaurant Syndrome is high, the question remains whether or not there is legitimate scientific evidence for this condition.  A large double blind study by Geha <em>et al</em> (2000) of people who self reported a sensitivity to MSG found that some individuals exhibited reactions to direct ingestion of MSG.  Results were neither consistent upon retesting nor were any of the effects persistent or serious.<sup><a href="http://justthescience.com/archives/785#footnote_5_785" id="identifier_5_785" class="footnote-link footnote-identifier-link" title="Multicenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate">6</a></sup>  Rosenblum <em>et al</em> (1971) found no difference in symptoms between individuals ingesting MSG and a placebo (Sodium Chloride (table salt)) and no symptoms resulting from this study matched those of CRS.<sup><a href="http://justthescience.com/archives/785#footnote_6_785" id="identifier_6_785" class="footnote-link footnote-identifier-link" title="Single and double blind studies with oral monosodium glutamate in man">7</a></sup>  Tarasoff and Kelly (1993) found no difference between a placebo and MSG when the MSG was ingested with food, even at high concentrations. <sup><a href="http://justthescience.com/archives/785#footnote_7_785" id="identifier_7_785" class="footnote-link footnote-identifier-link" title="Monosodium L-glutamate: a double-blind study and review">8</a></sup>  Woods <em>et al</em> (1998) and Woessner <em>et al</em> (1999)  found no link between MSG intake and asthma exasperation in asthmatics who self reported a sensitivity to MSG,<sup><a href="http://justthescience.com/archives/785#footnote_8_785" id="identifier_8_785" class="footnote-link footnote-identifier-link" title="The effects of monosodium glutamate in adults with asthma who perceive themselves to be monosodium glutamate&ndash;intolerant">9</a></sup><sup><a href="http://justthescience.com/archives/785#footnote_9_785" id="identifier_9_785" class="footnote-link footnote-identifier-link" title="Monosodium glutamate sensitivity in asthma">10</a></sup>  and Hawkins (2009) found that the blood/brain barrier is impermeable to glutamates.<sup><a href="http://justthescience.com/archives/785#footnote_10_785" id="identifier_10_785" class="footnote-link footnote-identifier-link" title="The blood-brain barrier and glutamate">11</a></sup> Finally, Burrin and Stoll (2009) found that natural and artificial dietary glutamates are metabolized in the same manner and are both a major oxidative fuel for the gut, an important precursor for a key neurotransmitter (glutathione).  <sup><a href="http://justthescience.com/archives/785#footnote_11_785" id="identifier_11_785" class="footnote-link footnote-identifier-link" title="Metabolic fate and function of dietary glutamate in the gut">12</a></sup></p>
<p><strong>Key Points</strong></p>
<ul>
<li>MSG is a major component of the food industry; 2009 global production levels estimated at 2 million tons.<sup><a href="http://justthescience.com/archives/785#footnote_12_785" id="identifier_12_785" class="footnote-link footnote-identifier-link" title="History of glutamate production">13</a></sup></li>
<li>MSG activates taste sensors responsible for the savory flavor (called &#8220;unami&#8221;).<sup><a href="http://justthescience.com/archives/785#footnote_13_785" id="identifier_13_785" class="footnote-link footnote-identifier-link" title="Functional neuroimaging of umami taste: what makes umami pleasant?">14</a></sup> <sup><a href="http://justthescience.com/archives/785#footnote_14_785" id="identifier_14_785" class="footnote-link footnote-identifier-link" title="Glutamate: from discovery as a food flavor to role as a basic taste (umami)">15</a></sup></li>
<li>MSG was attributed to a phenomenon called &#8220;Chinese Restaurant Syndrome.&#8221;  Afflicted individuals exhibited symptoms including burning sensations, and facial and chest pain, following eat at Chinese restaurants that used MSG as a food additive.<sup><a href="http://justthescience.com/archives/785#footnote_15_785" id="identifier_15_785" class="footnote-link footnote-identifier-link" title="Monosodium L-Glutamate: Its Pharmacology and Role in the Chinese Restaurant Syndrome">16</a></sup></li>
<li>A 2000 study reported inconsistent results that were neither persistent or serious to direct ingestion of MSG.<sup><a href="http://justthescience.com/archives/785#footnote_16_785" id="identifier_16_785" class="footnote-link footnote-identifier-link" title="Multicenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate">17</a></sup></li>
<li>1971 study found no difference in symptoms between individuals ingesting MSG or Sodium Chloride (table salt).<sup><a href="http://justthescience.com/archives/785#footnote_17_785" id="identifier_17_785" class="footnote-link footnote-identifier-link" title="Single and double blind studies with oral monosodium glutamate in man">18</a></sup></li>
<li>1993 study found no difference between individuals ingesting a MSG or a placebo with food or drink, even at high concentrations.<sup><a href="http://justthescience.com/archives/785#footnote_18_785" id="identifier_18_785" class="footnote-link footnote-identifier-link" title="Monosodium L-glutamate: a double-blind study and review">19</a></sup></li>
<li>1998 and 1999 studies found no link between MSG intake and asthma exasperation in asthmatics who self-reported a sensitivity to MSG.<sup><a href="http://justthescience.com/archives/785#footnote_19_785" id="identifier_19_785" class="footnote-link footnote-identifier-link" title="The effects of monosodium glutamate in adults with asthma who perceive themselves to be monosodium glutamate&ndash;intolerant">20</a></sup><sup><a href="http://justthescience.com/archives/785#footnote_20_785" id="identifier_20_785" class="footnote-link footnote-identifier-link" title="Monosodium glutamate sensitivity in asthma">21</a></sup></li>
<li>2009 study found blood/brain barrier is impermeable by glutamates (including MSG). <sup><a href="http://justthescience.com/archives/785#footnote_21_785" id="identifier_21_785" class="footnote-link footnote-identifier-link" title="The blood-brain barrier and glutamate">22</a></sup></li>
<li>2009 study found dietary glutamates are both a major oxidative fuel for the gut, and an important precursor for the neurotransmitter glutathione. <sup><a href="http://justthescience.com/archives/785#footnote_22_785" id="identifier_22_785" class="footnote-link footnote-identifier-link" title="Metabolic fate and function of dietary glutamate in the gut">23</a></sup></li>
</ul>
<ol class="footnotes"><li id="footnote_0_785" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/90/3/728S" target="_blank">History of glutamate production</a></li><li id="footnote_1_785" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/90/3/804S" target="_blank">Functional neuroimaging of umami taste: what makes umami pleasant?</a></li><li id="footnote_2_785" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/90/3/719S" target="_blank">Glutamate: from discovery as a food flavor to role as a basic taste (umami)</a></li><li id="footnote_3_785" class="footnote"><a href="http://http/www.sciencemag.org/cgi/content/abstract/163/3869/826" target="_blank">Monosodium L-Glutamate: Its Pharmacology and Role in the Chinese Restaurant Syndrome</a></li><li id="footnote_4_785" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/447978" target="_blank">Prevalence of the &#8220;Chinese restaurant syndrome&#8221;</a></li><li id="footnote_5_785" class="footnote"><a href="http://www.jacionline.org/article/S0091-6749%2800%2944233-8/abstract">Multicenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate</a></li><li id="footnote_6_785" class="footnote"><a href="http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6WXH-4DDR1WR-CW&amp;_user=10&amp;_rdoc=1&amp;_fmt=&amp;_orig=search&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_searchStrId=1140076009&amp;_rerunOrigin=scholar.google&amp;_acct=C000050221&amp;_version=1&amp;_urlVersion=0&amp;_userid=10&amp;md5=c47f05f521f50cf9ea70aa13914ae563">Single and double blind studies with oral monosodium glutamate in man</a></li><li id="footnote_7_785" class="footnote"><a href="http://grande.nal.usda.gov/ibids/index.php?mode2=detail&amp;origin=ibids_references&amp;therow=4335">Monosodium L-glutamate: a double-blind study and review</a></li><li id="footnote_8_785" class="footnote"><a href="http://www.jacionline.org/article/S0091-6749%2898%2970305-7/abstract">The effects of monosodium glutamate in adults with asthma who perceive themselves to be monosodium glutamate–intolerant</a></li><li id="footnote_9_785" class="footnote"><a href="http://www.jacionline.org/article/S0091-6749%2899%2970371-4/abstract">Monosodium glutamate sensitivity in asthma</a></li><li id="footnote_10_785" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/90/3/867S" target="_blank">The blood-brain barrier and glutamate</a></li><li id="footnote_11_785" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/90/3/850S">Metabolic fate and function of dietary glutamate in the gut</a></li><li id="footnote_12_785" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/90/3/728S" target="_blank">History of glutamate production</a></li><li id="footnote_13_785" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/90/3/804S" target="_blank">Functional neuroimaging of umami taste: what makes umami pleasant?</a></li><li id="footnote_14_785" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/90/3/719S" target="_blank">Glutamate: from discovery as a food flavor to role as a basic taste (umami)</a></li><li id="footnote_15_785" class="footnote"><a href="http://http/www.sciencemag.org/cgi/content/abstract/163/3869/826" target="_blank">Monosodium L-Glutamate: Its Pharmacology and Role in the Chinese Restaurant Syndrome</a></li><li id="footnote_16_785" class="footnote"><a href="http://www.jacionline.org/article/S0091-6749%2800%2944233-8/abstract">Multicenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate</a></li><li id="footnote_17_785" class="footnote"><a href="http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6WXH-4DDR1WR-CW&amp;_user=10&amp;_rdoc=1&amp;_fmt=&amp;_orig=search&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_searchStrId=1140076009&amp;_rerunOrigin=scholar.google&amp;_acct=C000050221&amp;_version=1&amp;_urlVersion=0&amp;_userid=10&amp;md5=c47f05f521f50cf9ea70aa13914ae563">Single and double blind studies with oral monosodium glutamate in man</a></li><li id="footnote_18_785" class="footnote"><a href="http://grande.nal.usda.gov/ibids/index.php?mode2=detail&amp;origin=ibids_references&amp;therow=4335">Monosodium L-glutamate: a double-blind study and review</a></li><li id="footnote_19_785" class="footnote"><a href="http://www.jacionline.org/article/S0091-6749%2898%2970305-7/abstract">The effects of monosodium glutamate in adults with asthma who perceive themselves to be monosodium glutamate–intolerant</a></li><li id="footnote_20_785" class="footnote"><a href="http://www.jacionline.org/article/S0091-6749%2899%2970371-4/abstract">Monosodium glutamate sensitivity in asthma</a></li><li id="footnote_21_785" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/90/3/867S" target="_blank">The blood-brain barrier and glutamate</a></li><li id="footnote_22_785" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/90/3/850S">Metabolic fate and function of dietary glutamate in the gut</a></li></ol>]]></content:encoded>
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		<title>Is Organic Produce Better for you?</title>
		<link>http://justthescience.com/archives/778</link>
		<comments>http://justthescience.com/archives/778#comments</comments>
		<pubDate>Wed, 14 Apr 2010 21:58:42 +0000</pubDate>
		<dc:creator></dc:creator>
				<category><![CDATA[Personal Health]]></category>

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		<description><![CDATA[The organic food industry has grown dramatically over the last several years, and it’s a natural assumption that eating organic foods is better for you.  Organic foods are grown in an environment perceived to be free of harmful pesticides and herbicides, and in some instances are deemed to be more nutritional than those grown in [...]]]></description>
			<content:encoded><![CDATA[<p>The organic food industry has grown dramatically over the last several years, and it’s a natural assumption that eating organic foods is better for you.  Organic foods are grown in an environment perceived to be free of harmful pesticides and herbicides, and in some instances are deemed to be more nutritional than those grown in a conventional manner.  Are there any significant differences between organic and normally raised agricultural products?</p>
<p>One well known difference between organically and non-organically grown produce are the chemicals, or lack thereof, utilized during the growing process.  Studies have found negative effects resulting from acute exposure to pesticides (Grandjean <em>et al</em> 2006) and herbicides (Kamel <em>et al</em> 2003) on farm workers and their children (if exposed prenatally).<sup><a href="http://justthescience.com/archives/778#footnote_0_778" id="identifier_0_778" class="footnote-link footnote-identifier-link" title="Pesticide Exposure and Stunting as Independent Predictors of Neurobehavioral Deficits in Ecuadorian School Children">1</a></sup><sup><a href="http://justthescience.com/archives/778#footnote_1_778" id="identifier_1_778" class="footnote-link footnote-identifier-link" title="Neurobehavioral performance and work experience in Florida farmworkers">2</a></sup>  For the consumers of produce from farms that utilize pesticides and herbicides, however, it’s been shown that actual exposure to these chemicals is relatively small.   Leblac <em>et </em>al (2000) determined that an average person&#8217;s exposure to pesticides is 4% of an individual’s maximum recommended exposure. <sup><a href="http://justthescience.com/archives/778#footnote_2_778" id="identifier_2_778" class="footnote-link footnote-identifier-link" title="Estimation of the dietary intake of pesticide residues, lead, cadmium, arsenic and radionuclides in France">3</a></sup>  Galal-Gorchev H. (1991) found that a person’s exposure to pesticide residue is well below established acceptable daily intake levels in the 21 western countries that supply data on the matter. <sup><a href="http://justthescience.com/archives/778#footnote_3_778" id="identifier_3_778" class="footnote-link footnote-identifier-link" title="Dietary intake of pesticide residues: cadmium, mercury, and lead">4</a></sup>   Juhler <em>et al</em> (1999) determined dietary exposure to pesticides does not affect male spermazoa,<sup><a href="http://justthescience.com/archives/778#footnote_4_778" id="identifier_4_778" class="footnote-link footnote-identifier-link" title="Human Semen Quality in Relation to Dietary Pesticide Exposure and Organic Diet">5</a></sup> and Safe (1995) found an individual&#8217;s exposure to estrogenic compounds from organochlorine pesticides is 0.0000025% of the daily intake of estrogenic flavonoids in the diet.<sup><a href="http://justthescience.com/archives/778#footnote_5_778" id="identifier_5_778" class="footnote-link footnote-identifier-link" title="Environmental and Dietary Estrogens and Human Health: Is There a Problem?">6</a></sup>  While organic farming has been shown to lower pesticide residues in food by 2/3, much organic produce is not pesticide free due to legacy contamination and drift from other fields (Baker <em>et al</em> 2002). <sup><a href="http://justthescience.com/archives/778#footnote_6_778" id="identifier_6_778" class="footnote-link footnote-identifier-link" title="Pesticide residues in conventional, IPM-grown and organic foods: Insights from three U.S. data sets">7</a></sup></p>
<p>As far as differences in nutritional value between organic and conventionally grown produce, much of the current literature is suggesting a need for further research, although some slightly notable differences have been found. A review of 55 articles on the subject found conventionally produced crops had significantly higher<sup> </sup>nitrogen content, and organically produced crops had significantly<sup> </sup>higher acidity and phosphorus content.  These differences were attributed to the difference in production methods and none of them had a material impact on the food&#8217;s nutritional value (Dangour <em>et al</em> 2009) (Bourne and Prescott 2002). <sup><a href="http://justthescience.com/archives/778#footnote_7_778" id="identifier_7_778" class="footnote-link footnote-identifier-link" title="Nutritional quality of organic foods: a systematic review">8</a></sup> <sup><a href="http://justthescience.com/archives/778#footnote_8_778" id="identifier_8_778" class="footnote-link footnote-identifier-link" title="A Comparison of the Nutritional Value, Sensory Qualities, and Food Safety of Organically and Conventionally Produced Foods">9</a></sup>  A study by Magkos <em>et al</em> (2003) found higher levels of ascorbic acid in organically grown leafy vegetables and potatoes and lower protein levels in some organic vegetables and cereals, but found this evidence to be inadequate to make a definitive argument.  A study by Caris-Veyrat <em>et al </em>(2004) found that organic tomatoes had higher levels of antioxidants (vitamin C, carotenoids, and polyphenols) than conventionally grown tomatoes, but when both types of tomatoes were fed to people for 3 weeks, no difference was found in antioxidant levels in the bloodstream between those that consumed organic or conventional. <sup><a href="http://justthescience.com/archives/778#footnote_9_778" id="identifier_9_778" class="footnote-link footnote-identifier-link" title="Organic food: nutritious food or food for thought? A review of the evidence">10</a></sup> <sup><a href="http://justthescience.com/archives/778#footnote_10_778" id="identifier_10_778" class="footnote-link footnote-identifier-link" title="Influence of Organic versus Conventional Agricultural Practice on the Antioxidant Microconstituent Content of Tomatoes and Derived Purees; Consequences on Antioxidant Plasma Status in Humans">11</a></sup>   Similarly, Tarozzi <em>et al</em> (2005) found that organic red oranges have a greater total antioxidant activity than those grown conventionally, but did not investigate whether or not the organic oranges would alter antioxidant levels in the bloodstream  <sup><a href="http://justthescience.com/archives/778#footnote_11_778" id="identifier_11_778" class="footnote-link footnote-identifier-link" title="Antioxidant effectiveness of organically and non-organically grown red oranges in cell culture systems">12</a></sup></p>
<ol class="footnotes"><li id="footnote_0_778" class="footnote"><a href="http://pediatrics.aappublications.org/cgi/content/full/117/3/e546?eaf" target="_blank">Pesticide Exposure and Stunting as Independent Predictors of Neurobehavioral Deficits in Ecuadorian School Children</a></li><li id="footnote_1_778" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241721/" target="_blank">Neurobehavioral performance and work experience in Florida farmworkers</a></li><li id="footnote_2_778" class="footnote"><a href="http://http/www.ingentaconnect.com/content/tandf/tfac/2000/00000017/00000011/art00005" target="_blank">Estimation of the dietary intake of pesticide residues, lead, cadmium, arsenic and radionuclides in France</a></li><li id="footnote_3_778" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/1812026" target="_blank">Dietary intake of pesticide residues: cadmium, mercury, and lead</a></li><li id="footnote_4_778" class="footnote"><a href="http://http/www.springerlink.com/content/c7htclh97bh02klp/" target="_blank">Human Semen Quality in Relation to Dietary Pesticide Exposure and Organic Diet</a></li><li id="footnote_5_778" class="footnote"><a href="http://ehp.niehs.nih.gov/members/1995/103-4/safe-full.html" target="_blank">Environmental and Dietary Estrogens and Human Health: Is There a Problem?</a></li><li id="footnote_6_778" class="footnote"><a href="http://www.omri.org/organic_summary.pdf" target="_blank">Pesticide residues in conventional, IPM-grown and organic foods: Insights from three U.S. data sets</a></li><li id="footnote_7_778" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/90/3/680">Nutritional quality of organic foods: a systematic review</a></li><li id="footnote_8_778" class="footnote"><a href="A Comparison of the Nutritional Value, Sensory Qualities, and  Food Safety of Organically and Conventionally Produced Foods" target="_blank">A Comparison of the Nutritional Value, Sensory Qualities, and Food Safety of Organically and Conventionally Produced Foods</a></li><li id="footnote_9_778" class="footnote"><a href="http://www.informaworld.com/smpp/content~content=a713995042&amp;db=all" target="_blank">Organic food: nutritious food or food for thought? A review of the evidence</a></li><li id="footnote_10_778" class="footnote"><a href="http://pubs.acs.org/doi/abs/10.1021/jf0346861" target="_blank">Influence of Organic versus Conventional Agricultural Practice on the Antioxidant Microconstituent Content of Tomatoes and Derived Purees; Consequences on Antioxidant Plasma Status in Humans</a></li><li id="footnote_11_778" class="footnote"><a href="http://www.springerlink.com/content/r450120322113178/" target="_blank">Antioxidant effectiveness of organically and non-organically grown red oranges in cell culture systems</a></li></ol>]]></content:encoded>
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		<title>Does it matter when you eat?</title>
		<link>http://justthescience.com/archives/681</link>
		<comments>http://justthescience.com/archives/681#comments</comments>
		<pubDate>Fri, 13 Nov 2009 06:45:17 +0000</pubDate>
		<dc:creator></dc:creator>
				<category><![CDATA[Personal Health]]></category>
		<category><![CDATA[basal metabolic rate]]></category>
		<category><![CDATA[bedtime]]></category>
		<category><![CDATA[breakfast]]></category>
		<category><![CDATA[eating]]></category>
		<category><![CDATA[fat]]></category>
		<category><![CDATA[feeding frequency]]></category>
		<category><![CDATA[feeding timing]]></category>
		<category><![CDATA[fewer concentrated meals]]></category>
		<category><![CDATA[late night eating]]></category>
		<category><![CDATA[metabolic]]></category>
		<category><![CDATA[obesity]]></category>
		<category><![CDATA[overeating]]></category>
		<category><![CDATA[overindulge]]></category>
		<category><![CDATA[prepared portion of food]]></category>
		<category><![CDATA[short-term metabolic effects]]></category>
		<category><![CDATA[sleeping]]></category>
		<category><![CDATA[smaller meals]]></category>
		<category><![CDATA[Theories]]></category>

		<guid isPermaLink="false">http://justthescience.com/?p=681</guid>
		<description><![CDATA[There have been many different theories regarding when and how often an individual should eat, among them: including vs. skipping breakfast, not eating anything before bedtime, and eating several smaller meals vs. fewer concentrated meals.  In this article, we intend to examine whether or not feeding timing and frequency is relevant to metabolism, and/or satiation. [...]]]></description>
			<content:encoded><![CDATA[<p>There have been many different theories regarding when and how often an individual should eat, among them: including vs. skipping breakfast, not eating anything before bedtime, and eating several smaller meals vs. fewer concentrated meals.  In this article, we intend to examine whether or not feeding timing and frequency is relevant to metabolism, and/or satiation.</p>
<p>Including breakfast in one’s day has been shown to have myriad effects.  De Castro (2004) found those that skip breakfast are more likely to overeat later. <sup><a href="http://justthescience.com/archives/681#footnote_0_681" id="identifier_0_681" class="footnote-link footnote-identifier-link" title="The time of day of food intake influences overall intake in humans">1</a></sup>   Additionally, Schlundt <em>et al</em> (1992) and Stubbs <em>et al</em> (1996) found those that eat breakfast eat less fat throughout the day and are less prone to impulsive eating of familiar foods. <sup><a href="http://justthescience.com/archives/681#footnote_1_681" id="identifier_1_681" class="footnote-link footnote-identifier-link" title="The role of breakfast in the treatment of obesity: a randomized clinical trial">2</a></sup><sup><a href="http://justthescience.com/archives/681#footnote_2_681" id="identifier_2_681" class="footnote-link footnote-identifier-link" title="Breakfasts high in protein, fat or carbohydrate: effect on within-day appetite and energy balance">3</a></sup> However, multiple studies have found that feeding frequency and timing does not have an effect on metabolic performance (Wilhelmine <em>et al</em> 1998) (Dallosso <em>et al 1982) (</em> Verboeket van de Venne and Westerterp 1998) (Wolfram <em>et al</em> 1987). <sup><a href="http://justthescience.com/archives/681#footnote_3_681" id="identifier_3_681" class="footnote-link footnote-identifier-link" title="Effect of the pattern of food intake on human energy metabolism">4</a></sup> <sup><a href="http://justthescience.com/archives/681#footnote_4_681" id="identifier_4_681" class="footnote-link footnote-identifier-link" title="Feeding frequency and energy balance in adult males">5</a></sup> <sup><a href="http://justthescience.com/archives/681#footnote_5_681" id="identifier_5_681" class="footnote-link footnote-identifier-link" title="Frequency of feeding, weight reduction and energy metabolism">6</a></sup> <sup><a href="http://justthescience.com/archives/681#footnote_6_681" id="identifier_6_681" class="footnote-link footnote-identifier-link" title="Thermogenesis in humans after varying meal time frequency">7</a></sup> In addition, Goldberg <em>et al</em> (1998) found that one’s metabolic rate while sleeping is roughly concurrent with one’s basal metabolic rate (BMR), which in combination with results from the previously mentioned studies suggests that there are no adverse metabolic effects from eating before sleeping.<sup><a href="http://justthescience.com/archives/681#footnote_7_681" id="identifier_7_681" class="footnote-link footnote-identifier-link" title="Overnight and basal metabolic rates in men and women">8</a></sup>  However, it is important if you are partaking in late night eating that you eat a prepared portion of food, as it’s been demonstrated that it&#8217;s common for individuals to overindulge late (Waller <em>et al</em> 2004). <sup><a href="http://justthescience.com/archives/681#footnote_8_681" id="identifier_8_681" class="footnote-link footnote-identifier-link" title="Evening Ready-to-Eat Cereal Consumption Contributes to Weight Management">9</a></sup></p>
<p>Eating more frequent smaller meals has been shown to decrease future hunger more effectively than eating few highly concentrated meals (Speechly and Buffenstein 1999).  Johnstone <em>et al</em> (2000) found similar results in their study, and also determined that the nutritional composition of these smaller meals (i.e. high in protein, fat, or carbohydrates) did not affect later decreased hunger, provided they contained a similar caloric composition<sup><a href="http://justthescience.com/archives/681#footnote_9_681" id="identifier_9_681" class="footnote-link footnote-identifier-link" title="Greater Appetite Control Associated with an Increased Frequency of Eating in Lean Males">10</a></sup> <sup><a href="http://justthescience.com/archives/681#footnote_10_681" id="identifier_10_681" class="footnote-link footnote-identifier-link" title="Altering the temporal distribution of energy intake with isoenergetically dense foods given as snacks does not affect total daily energy intake in normal-weight men">11</a></sup></p>
<ol class="footnotes"><li id="footnote_0_681" class="footnote"><a href="http://jn.nutrition.org/cgi/content/full/134/1/104">The time of day of food intake influences overall intake in humans</a></li><li id="footnote_1_681" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/55/3/645">The role of breakfast in the treatment of obesity: a randomized clinical trial</a></li><li id="footnote_2_681" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/8862476">Breakfasts high in protein, fat or carbohydrate: effect on within-day appetite and energy balance</a></li><li id="footnote_3_681" class="footnote"><a href="http://journals.cambridge.org/action/displayAbstract?fromPage=online&amp;aid=873508">Effect of the pattern of food intake on human energy metabolism</a></li><li id="footnote_4_681" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/7076516">Feeding frequency and energy balance in adult males</a></li><li id="footnote_5_681" class="footnote"><a href="http://grande.nal.usda.gov/ibids/index.php?mode2=detail&amp;origin=ibids_references&amp;therow=81268">Frequency of feeding, weight reduction and energy metabolism</a></li><li id="footnote_6_681" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/3592618">Thermogenesis in humans after varying meal time frequency</a></li><li id="footnote_7_681" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/3378547">Overnight and basal metabolic rates in men and women</a></li><li id="footnote_8_681" class="footnote"><a href="http://www.jacn.org/cgi/content/abstract/23/4/316">Evening Ready-to-Eat Cereal Consumption Contributes to Weight Management</a></li><li id="footnote_9_681" class="footnote"><a href="http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6WB2-45GW6BS-2&amp;_user=10&amp;_rdoc=1&amp;_fmt=&amp;_orig=search&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_searchStrId=1085330660&amp;_rerunOrigin=scholar.google&amp;_acct=C000050221&amp;_version=1&amp;_urlVersion=0&amp;_userid=10&amp;md5=e9cf7c64a27f1bcda0da8687867f437f">Greater Appetite Control Associated with an Increased Frequency of Eating in Lean Males</a></li><li id="footnote_10_681" class="footnote"><a href="http://journals.cambridge.org/action/displayAbstract?fromPage=online&amp;aid=878712">Altering the temporal distribution of energy intake with isoenergetically dense foods given as snacks does not affect total daily energy intake in normal-weight men</a></li></ol>]]></content:encoded>
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		<title>Are there benefits to stretching before or after exercise?</title>
		<link>http://justthescience.com/archives/619</link>
		<comments>http://justthescience.com/archives/619#comments</comments>
		<pubDate>Fri, 06 Nov 2009 03:35:58 +0000</pubDate>
		<dc:creator></dc:creator>
				<category><![CDATA[Personal Health]]></category>
		<category><![CDATA[anaerobic capacity]]></category>
		<category><![CDATA[athletic regimen]]></category>
		<category><![CDATA[ballistic stretching]]></category>
		<category><![CDATA[benefits]]></category>
		<category><![CDATA[concentric muscle movements]]></category>
		<category><![CDATA[dearth]]></category>
		<category><![CDATA[dynamic stretching]]></category>
		<category><![CDATA[endurance running]]></category>
		<category><![CDATA[exercise]]></category>
		<category><![CDATA[extended range of motion]]></category>
		<category><![CDATA[flexibility]]></category>
		<category><![CDATA[high speed running]]></category>
		<category><![CDATA[jumpting height]]></category>
		<category><![CDATA[ligament injuries]]></category>
		<category><![CDATA[momentum]]></category>
		<category><![CDATA[muscle activation]]></category>
		<category><![CDATA[muscle injuries]]></category>
		<category><![CDATA[performance]]></category>
		<category><![CDATA[power endurance]]></category>
		<category><![CDATA[propel]]></category>
		<category><![CDATA[range of motion]]></category>
		<category><![CDATA[risk of injury]]></category>
		<category><![CDATA[routine]]></category>
		<category><![CDATA[running economy]]></category>
		<category><![CDATA[soreness]]></category>
		<category><![CDATA[sprinting]]></category>
		<category><![CDATA[static stretching]]></category>
		<category><![CDATA[stretching]]></category>
		<category><![CDATA[tendon injuries]]></category>

		<guid isPermaLink="false">http://justthescience.com/?p=619</guid>
		<description><![CDATA[Stretching prior to, and following exercise is a commonly recommended practice.  Whether or not there are benefits in including this in one’s routine is a controversial subject.  Studies exist that have found little to no benefit of including stretching as part of an athletic regimen (Thacker et al 2004). 1  Other studies exist that have found [...]]]></description>
			<content:encoded><![CDATA[<p>Stretching prior to, and following exercise is a commonly recommended practice.  Whether or not there are benefits in including this in one’s routine is a controversial subject.  Studies exist that have found little to no benefit of including stretching as part of an athletic regimen (Thacker <em>et al</em> 2004). <sup><a href="http://justthescience.com/archives/619#footnote_0_619" id="identifier_0_619" class="footnote-link footnote-identifier-link" title="The Impact of Stretching on Sports Injury Risk: A Systematic Review of the Literature">1</a></sup>  Other studies exist that have found stretching before or after athletic activity slightly reduces muscle, ligament, and tendon injuries as well as soreness (Jamtvedt <em>et al</em> 2009). <sup><a href="http://justthescience.com/archives/619#footnote_1_619" id="identifier_1_619" class="footnote-link footnote-identifier-link" title="A pragmatic randomised trial of stretching before and after physical activity to prevent injury and soreness">2</a></sup> In addition, Herbert and Gabriel (2002) found that stretching before or after exercising does<sup> </sup>not confer protection from muscle soreness and that stretching before<sup> </sup>exercising does not practically reduce the risk of injury.<sup><a href="http://justthescience.com/archives/619#footnote_2_619" id="identifier_2_619" class="footnote-link footnote-identifier-link" title="Effects of stretching before and after exercising on muscle soreness and risk of injury: systematic review">3</a></sup> In this article, we intend to examine in more details whether or not there are benefits associated with incorporating the three major types of stretching (static, dynamic, and ballistic) as part of a regular exercise routine.</p>
<p>Static stretching takes place when an individual&#8217;s body is at rest, and one holds each stretch for thirty seconds to one minute.  In individuals who are not yet fully involved in a committed athletic program, evidence exists that static stretching can help them ease into a new program without stressing the body (Kokkonen <em>et al</em> 2007).<sup><a href="http://justthescience.com/archives/619#footnote_3_619" id="identifier_3_619" class="footnote-link footnote-identifier-link" title="Chronic Static Stretching Improves Exercise Performance">4</a></sup>  Static stretching also increases torque in concentric muscle movements (Cramer <em>et al</em> 2006), flexibility (O&#8217;Sullivan <em>et al</em> 2009), and range of motion over the long term (LaRoche and Connolly 2006).  Static stretching has otherwise been found have no or negative effects on athletic performance, including a reduction in muscle power endurance, (Yamaguchi <em>et al</em> 2006) (Yamaguchi and Ishii 2005) (Nelson <em>et al</em> 2005) (Brandenburg 2006), sprinting and endurance running performance (Fletcher and Anness 2007) (Wilson <em>et al</em> 2008) (Heyes and Walker 2007), muscle activation (Cramer <em>et al</em> 2004), and jumping height (Holt and Lambourne 2008) (Bradly <em>et al</em> 2007). <sup><a href="http://justthescience.com/archives/619#footnote_4_619" id="identifier_4_619" class="footnote-link footnote-identifier-link" title="Acute Effects of Static Stretching on Maximal Eccentric Torque Production in Women">5</a></sup> <sup><a href="http://justthescience.com/archives/619#footnote_5_619" id="identifier_5_619" class="footnote-link footnote-identifier-link" title="Effects of Static Stretching for 30 Seconds and Dynamic Stretching on Leg Extension Power">6</a></sup> <sup><a href="http://justthescience.com/archives/619#footnote_6_619" id="identifier_6_619" class="footnote-link footnote-identifier-link" title="Acute Effect of Static Stretching on Power Output During Concentric Dynamic Constant External Resistance Leg Extension">7</a></sup> <sup><a href="http://justthescience.com/archives/619#footnote_7_619" id="identifier_7_619" class="footnote-link footnote-identifier-link" title="Acute Muscle Stretching Inhibits Muscle Strength Endurance Performance">8</a></sup><sup><a href="http://justthescience.com/archives/619#footnote_8_619" id="identifier_8_619" class="footnote-link footnote-identifier-link" title="Duration of stretch does not influence the degree of force loss following static stretching">9</a></sup> <sup><a href="http://justthescience.com/archives/619#footnote_9_619" id="identifier_9_619" class="footnote-link footnote-identifier-link" title="The Acute Effects of Combined Static and Dynamic Stretch Protocols on Fifty-Meter Sprint Performance in Track-and-Field Athletes">10</a></sup> <sup><a href="http://justthescience.com/archives/619#footnote_10_619" id="identifier_10_619" class="footnote-link footnote-identifier-link" title="The effect of warm-up, static stretching and dynamic stretching on hamstring flexibility in previously injured subjects">11</a></sup> <sup><a href="http://justthescience.com/archives/619#footnote_11_619" id="identifier_11_619" class="footnote-link footnote-identifier-link" title="Pre-exercise stretching does not impact upon running economy">12</a></sup> <sup><a href="http://justthescience.com/archives/619#footnote_12_619" id="identifier_12_619" class="footnote-link footnote-identifier-link" title="The acute effects of static stretching on peak torque, mean power output, electromyography, and mechanomyography">13</a></sup><sup><a href="http://justthescience.com/archives/619#footnote_13_619" id="identifier_13_619" class="footnote-link footnote-identifier-link" title="The Effects Of Static Stretching On Energy Cost And Endurance Performance During Treadmill Running">14</a></sup> <sup><a href="http://justthescience.com/archives/619#footnote_14_619" id="identifier_14_619" class="footnote-link footnote-identifier-link" title="The Effect of Static,Ballistic, and Proprioceptive Neuromuscular Facilitation Stretching on Vertical Jump Performance">15</a></sup> <sup><a href="http://justthescience.com/archives/619#footnote_15_619" id="identifier_15_619" class="footnote-link footnote-identifier-link" title="The Impact of Different Warm-Up Protocols on Vertical Jump Performance in Male Collegiate Athletes">16</a></sup> <sup><a href="http://justthescience.com/archives/619#footnote_16_619" id="identifier_16_619" class="footnote-link footnote-identifier-link" title="Effects of Stretching on Passive Muscle Tension and Response to Eccentric Exercise">17</a></sup></p>
<p>Dynamic stretching utilizes momentum from form to propel the body beyond in an extended range of motion.  This has been shown to have the greatest positive effect on a range of metrics, including improved muscular power (Yamaguchi and Ishii 2005), sprinting (Fletcher and Anness 2007), and high speed running performance (Little and Williams 2006).<sup><a href="http://justthescience.com/archives/619#footnote_17_619" id="identifier_17_619" class="footnote-link footnote-identifier-link" title="Effects of Static Stretching for 30 Seconds and Dynamic Stretching on Leg Extension Power">18</a></sup> <sup><a href="http://justthescience.com/archives/619#footnote_18_619" id="identifier_18_619" class="footnote-link footnote-identifier-link" title="The Acute Effects of Combined Static and Dynamic Stretch Protocols on Fifty-Meter Sprint Performance in Track-and-Field Athletes">19</a></sup> <sup><a href="http://justthescience.com/archives/619#footnote_19_619" id="identifier_19_619" class="footnote-link footnote-identifier-link" title="Effects of Differential Stretching Protocols During Warm-Ups on High-Speed Motor Capacities in Professional Soccer Players">20</a></sup> A long-term dynamic stretching program has been positively correlated with sustained muscle power, strength, muscular endurance, anaerobic capacity, and agility performance enhancements (Herman and Smith 2008).<sup><a href="http://justthescience.com/archives/619#footnote_20_619" id="identifier_20_619" class="footnote-link footnote-identifier-link" title="Four-Week Dynamic Stretching Warm-up Intervention Elicits Longer-Term Performance Benefits">21</a></sup>  However, it has not been shown to improve running economy (Heyes and Walker 2007). <sup><a href="http://justthescience.com/archives/619#footnote_21_619" id="identifier_21_619" class="footnote-link footnote-identifier-link" title="Pre-exercise stretching does not impact upon running economy">22</a></sup></p>
<p>Ballistic stretching uses bouncing movements to force limbs into an extended range of motion when the muscle has not relaxed enough to enter it.  Studies have shown the existence of some benefits, including improved vertical jump height (Woolstenhulme <em>et al</em> 2006) and general range of motion as a result of ballistic stretching (LaRoche and Connolly 2006).<sup><a href="http://justthescience.com/archives/619#footnote_22_619" id="identifier_22_619" class="footnote-link footnote-identifier-link" title="Ballistic Stretching Increases Flexibility and Acute Vertical Jump Height When Combined With Basketball Activity">23</a></sup> <sup><a href="http://justthescience.com/archives/619#footnote_23_619" id="identifier_23_619" class="footnote-link footnote-identifier-link" title="Effects of Stretching on Passive Muscle Tension and Response to Eccentric Exercise">24</a></sup>  Compared to the other two types, there is a dearth of research on ballistic stretching specifically comparisons between ballistic and dynamic stretching.</p>
<p>In short, due to the different benefits of the three types of stretching it is important to make sure that your stretching program will benefit your athletic regimen and not undermine it.</p>
<ol class="footnotes"><li id="footnote_0_619" class="footnote"><a href="http://journals.lww.com/acsm-msse/Abstract/2004/03000/The_Impact_of_Stretching_on_Sports_Injury_Risk__A.4.aspx"><span style="color: #000cf2; text-decoration: underline;">The Impact of Stretching on Sports Injury Risk: A Systematic Review of the Literature</span></a></li><li id="footnote_1_619" class="footnote"><a href="http://bjsportmed.com/cgi/content/abstract/bjsm.2009.062232v1"><span style="color: #000cf2; text-decoration: underline;">A pragmatic randomised trial of stretching before and after physical activity to prevent injury and soreness</span></a></li><li id="footnote_2_619" class="footnote"><a href="http://www.bmj.com/cgi/content/full/325/7362/468?session=hq9ZbGqlAqdh6vZa41nfd4Gce6"><span style="color: #000cf2; text-decoration: underline;">Effects of stretching before and after exercising on muscle soreness and risk of injury: systematic review</span></a></li><li id="footnote_3_619" class="footnote"><a href="http://journals.lww.com/acsm-msse/Abstract/2007/10000/Chronic_Static_Stretching_Improves_Exercise.20.aspx"><span style="color: #000cf2; text-decoration: underline;">Chronic Static Stretching Improves Exercise Performance</span></a></li><li id="footnote_4_619" class="footnote"><a href="http://journals.lww.com/nsca-jscr/pages/articleviewer.aspx?year=2006&amp;issue=05000&amp;article=00020&amp;type=abstract"><span style="color: #000cf2; text-decoration: underline;">Acute Effects of Static Stretching on Maximal Eccentric Torque Production in Women</span></a></li><li id="footnote_5_619" class="footnote"><a href="http://journals.lww.com/nsca-jscr/Abstract/2005/08000/Effects_of_Static_Stretching_for_30_Seconds_and.32.aspx"><span style="color: #000cf2; text-decoration: underline;">Effects of Static Stretching for 30 Seconds and Dynamic Stretching on Leg Extension Power</span></a></li><li id="footnote_6_619" class="footnote"><a href="http://journals.lww.com/nsca-jscr/Abstract/2006/11000/Acute_Effect_of_Static_Stretching_on_Power_Output.13.aspx"><span style="color: #000cf2; text-decoration: underline;">Acute Effect of Static Stretching on Power Output During Concentric Dynamic Constant External Resistance Leg Extension</span></a></li><li id="footnote_7_619" class="footnote"><a href="http://apt.allenpress.com/perlserv/?request=get-abstract&amp;doi=10.1519/R-15894.1&amp;ct=1"><span style="color: #000cf2; text-decoration: underline;">Acute Muscle Stretching Inhibits Muscle Strength Endurance Performance</span></a></li><li id="footnote_8_619" class="footnote"><a href="http://cat.inist.fr/?aModele=afficheN&amp;cpsidt=18431117"><span style="color: #000cf2; text-decoration: underline;">Duration of stretch does not influence the degree of force loss following static stretching</span></a></li><li id="footnote_9_619" class="footnote"><a href="http://journals.lww.com/nsca-jscr/Abstract/2007/08000/The_Acute_Effects_of_Combined_Static_and_Dynamic.22.aspx"><span style="color: #000cf2; text-decoration: underline;">The Acute Effects of Combined Static and Dynamic Stretch Protocols on Fifty-Meter Sprint Performance in Track-and-Field Athletes</span></a></li><li id="footnote_10_619" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679703/?tool=pmcentrez&amp;report=abstract"><span style="color: #000cf2; text-decoration: underline;">The effect of warm-up, static stretching and dynamic stretching on hamstring flexibility in previously injured subjects</span></a></li><li id="footnote_11_619" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/18076223"><span style="color: #000cf2; text-decoration: underline;">Pre-exercise stretching does not impact upon running economy</span></a></li><li id="footnote_12_619" class="footnote"><a href="http://www.springerlink.com/content/xqld6t74ftye0y2j/"><span style="color: #000cf2; text-decoration: underline;">The acute effects of static stretching on peak torque, mean power output, electromyography, and mechanomyography</span></a></li><li id="footnote_13_619" class="footnote"><a href="http://journals.lww.com/acsm-msse/Fulltext/2008/05001/The_Effects_Of_Static_Stretching_On_Energy_Cost.875.aspx"><span style="color: #000cf2; text-decoration: underline;">The Effects Of Static Stretching On Energy Cost And Endurance Performance During Treadmill Running</span></a></li><li id="footnote_14_619" class="footnote"><a href="http://journals.lww.com/nsca-jscr/Abstract/2007/02000/The_Effect_of_Static,Ballistic,_and_Proprioceptive.40.aspx"><span style="color: #000cf2; text-decoration: underline;">The Effect of Static,Ballistic, and Proprioceptive Neuromuscular Facilitation Stretching on Vertical Jump Performance</span></a></li><li id="footnote_15_619" class="footnote"><a href="http://journals.lww.com/nsca-jscr/Abstract/2008/01000/The_Impact_of_Different_Warm_Up_Protocols_on.33.aspx"><span style="color: #000cf2; text-decoration: underline;">The Impact of Different Warm-Up Protocols on Vertical Jump Performance in Male Collegiate Athletes</span></a></li><li id="footnote_16_619" class="footnote"><a href="http://ajs.sagepub.com/content/34/6/1000.abstract"><span style="color: #000cf2; text-decoration: underline;">Effects of Stretching on Passive Muscle Tension and Response to Eccentric Exercise</span></a></li><li id="footnote_17_619" class="footnote"><a href="http://journals.lww.com/nsca-jscr/Abstract/2005/08000/Effects_of_Static_Stretching_for_30_Seconds_and.32.aspx"><span style="color: #000cf2; text-decoration: underline;">Effects of Static Stretching for 30 Seconds and Dynamic Stretching on Leg Extension Power</span></a></li><li id="footnote_18_619" class="footnote"><a href="http://journals.lww.com/nsca-jscr/Abstract/2007/08000/The_Acute_Effects_of_Combined_Static_and_Dynamic.22.aspx"><span style="color: #000cf2; text-decoration: underline;">The Acute Effects of Combined Static and Dynamic Stretch Protocols on Fifty-Meter Sprint Performance in Track-and-Field Athletes</span></a></li><li id="footnote_19_619" class="footnote"><a href="http://journals.lww.com/nsca-jscr/Abstract/2006/02000/Effects_of_Differential_Stretching_Protocols.33.aspx"><span style="color: #000cf2; text-decoration: underline;">Effects of Differential Stretching Protocols During Warm-Ups on High-Speed Motor Capacities in Professional Soccer Players</span></a></li><li id="footnote_20_619" class="footnote"><a href="http://journals.lww.com/nsca-jscr/Abstract/2008/07000/Four_Week_Dynamic_Stretching_Warm_up_Intervention.36.aspx"><span style="color: #000cf2; text-decoration: underline;">Four-Week Dynamic Stretching Warm-up Intervention Elicits Longer-Term Performance Benefits</span></a></li><li id="footnote_21_619" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/18076223"><span style="color: #000cf2; text-decoration: underline;">Pre-exercise stretching does not impact upon running economy</span></a></li><li id="footnote_22_619" class="footnote"><a href="http://journals.lww.com/nsca-jscr/Abstract/2006/11000/Ballistic_Stretching_Increases_Flexibility_and.12.aspx"><span style="color: #000cf2; text-decoration: underline;">Ballistic Stretching Increases Flexibility and Acute Vertical Jump Height When Combined With Basketball Activity</span></a></li><li id="footnote_23_619" class="footnote"><a href="http://ajs.sagepub.com/content/34/6/1000.abstract"><span style="color: #000cf2; text-decoration: underline;">Effects of Stretching on Passive Muscle Tension and Response to Eccentric Exercise</span></a></li></ol>]]></content:encoded>
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		<title>High Fructose Corn Syrup; good or bad?</title>
		<link>http://justthescience.com/archives/563</link>
		<comments>http://justthescience.com/archives/563#comments</comments>
		<pubDate>Thu, 22 Oct 2009 16:14:14 +0000</pubDate>
		<dc:creator></dc:creator>
				<category><![CDATA[Personal Health]]></category>
		<category><![CDATA[caloric sweeteners]]></category>
		<category><![CDATA[chronic diseases]]></category>
		<category><![CDATA[Coke]]></category>
		<category><![CDATA[diabetes]]></category>
		<category><![CDATA[dietary allowance]]></category>
		<category><![CDATA[ectopic lipid]]></category>
		<category><![CDATA[food]]></category>
		<category><![CDATA[fructose]]></category>
		<category><![CDATA[fruit]]></category>
		<category><![CDATA[HFCS]]></category>
		<category><![CDATA[high fructose corn syrup]]></category>
		<category><![CDATA[insulin]]></category>
		<category><![CDATA[insulin resistance]]></category>
		<category><![CDATA[metabolic]]></category>
		<category><![CDATA[milk]]></category>
		<category><![CDATA[obesity]]></category>
		<category><![CDATA[satiety]]></category>
		<category><![CDATA[short-term metabolic effects]]></category>
		<category><![CDATA[sucrose]]></category>
		<category><![CDATA[sweeteners]]></category>
		<category><![CDATA[westernization]]></category>

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		<description><![CDATA[As levels of diabetes, obesity, and other dietary issues increase (diabetes alone has increased 763% from 1935 to 1996 in the united states (Gross et al 2004)) studies have been conducted to investigate whether the 1,000% rise in the use of High Fructose Corn Syrup (HFCS) from 1967 to 2000 in the American food industry [...]]]></description>
			<content:encoded><![CDATA[<p>As levels of diabetes, obesity, and other dietary issues increase (diabetes alone has increased 763% from 1935 to 1996 in the united states (Gross <em>et al</em> 2004)) studies have been conducted to investigate whether the 1,000% rise in the use of High Fructose Corn Syrup (HFCS) from 1967 to 2000 in the American food industry is a major contributor (Bray <em>et al</em> 2004).<sup><a href="http://justthescience.com/archives/563#footnote_0_563" id="identifier_0_563" class="footnote-link footnote-identifier-link" title="Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity">1</a></sup>  <sup><a href="http://justthescience.com/archives/563#footnote_1_563" id="identifier_1_563" class="footnote-link footnote-identifier-link" title="Fructose, insulin resistance, and metabolic dyslipidemia">2</a></sup> In this article, we will examine whether or not HFCS is truly a factor in this significant increase.</p>
<p>Early studies found that there were possible clinical explanations for metabolic differences derived from HFCS ingestion and other sweeteners; primarily that it did not trigger insulin creation and thereby was thought to not trigger satiety signals (Reiser <em>et al</em> 1989) (Elliott <em>et al</em> 2002) (Bray <em>et al</em> 2004) (Teff <em>et al</em> 2004) .<sup><a href="http://justthescience.com/archives/563#footnote_2_563" id="identifier_2_563" class="footnote-link footnote-identifier-link" title="Fructose, weight gain, and the insulin resistance syndrome">3</a></sup> <sup><a href="http://justthescience.com/archives/563#footnote_3_563" id="identifier_3_563" class="footnote-link footnote-identifier-link" title="Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity">4</a></sup> <sup><a href="http://justthescience.com/archives/563#footnote_4_563" id="identifier_4_563" class="footnote-link footnote-identifier-link" title="Dietary Fructose Reduces Circulating Insulin and Leptin, Attenuates Postprandial Suppression of Ghrelin, and Increases Triglycerides in Women">5</a></sup> <sup><a href="http://justthescience.com/archives/563#footnote_5_563" id="identifier_5_563" class="footnote-link footnote-identifier-link" title="Day-long glucose, insulin, and fructose responses of hyperinsulinemic and nonhyperinsulinemic men adapted to diets containing either fructose or high-amylose cornstarch">6</a></sup>  However, more recent studies have found no difference in resulting satiety in men or women resulting from HFCS, sucrose, or milk, (Soenen and Westerterp-Plantenga 2007) (Melanson <em>et al 2008)</em> (Akhavan and Anderson 2007),<sup><a href="http://justthescience.com/archives/563#footnote_6_563" id="identifier_6_563" class="footnote-link footnote-identifier-link" title="No differences in satiety or energy intake after high-fructose corn syrup, sucrose, or milk preloads">7</a></sup> <sup><a href="http://justthescience.com/archives/563#footnote_7_563" id="identifier_7_563" class="footnote-link footnote-identifier-link" title="High-fructose corn syrup, energy intake, and appetite regulation">8</a></sup> <sup><a href="http://justthescience.com/archives/563#footnote_8_563" id="identifier_8_563" class="footnote-link footnote-identifier-link" title="Effects of glucose-to-fructose ratios in solutions on subjective satiety, food intake, and satiety hormones in young men">9</a></sup> and that HFCS yields similar metabolic responses to other caloric sweeteners. (Angelopoulos <em>et al</em> 2009),<sup><a href="http://justthescience.com/archives/563#footnote_9_563" id="identifier_9_563" class="footnote-link footnote-identifier-link" title="The Effect of High-Fructose Corn Syrup Consumption on Triglycerides and Uric Acid">10</a></sup> Stanhope <em>et al</em> 2008 and Melanson  <em>et al</em> 2007 determined that sucrose and HFCS do not have significantly different short-term metabolic effects,<sup><a href="http://justthescience.com/archives/563#footnote_10_563" id="identifier_10_563" class="footnote-link footnote-identifier-link" title="Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals">11</a></sup> <sup><a href="http://justthescience.com/archives/563#footnote_11_563" id="identifier_11_563" class="footnote-link footnote-identifier-link" title="Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women">12</a></sup> and moderate levels (~1.5 grams of fructose per kilogram of body mass) of HFCS intake  does not cause ectopic lipid deposition or insulin resistance in healthy humans (Le <em>et al</em> 2006).<sup><a href="http://justthescience.com/archives/563#footnote_12_563" id="identifier_12_563" class="footnote-link footnote-identifier-link" title="A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans">13</a></sup></p>
<p>Although HFCS is not itself responsible for the increase in dietary and metabolic disorders, other studies have demonstrated that increasing levels of excess energy consumption in general is a cause (Gross <em>et al</em> 2004).<sup><a href="http://justthescience.com/archives/563#footnote_13_563" id="identifier_13_563" class="footnote-link footnote-identifier-link" title="Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment">14</a></sup>  For thousands of years humans consumed fructose amounting to 16–20 grams per day, largely from fresh fruits (Gross <em>et al</em> 2004). <sup><a href="http://justthescience.com/archives/563#footnote_14_563" id="identifier_14_563" class="footnote-link footnote-identifier-link" title="Fructose, insulin resistance, and metabolic dyslipidemia">15</a></sup> Westernization of diets has resulted in significant increases in food with added fructose, leading to typical daily consumptions amounting to 85–100 grams of fructose per day (Gross <em>et al</em> 2004). <sup><a href="http://justthescience.com/archives/563#footnote_15_563" id="identifier_15_563" class="footnote-link footnote-identifier-link" title="Fructose, insulin resistance, and metabolic dyslipidemia">16</a></sup>  For example, a 12 ounce Coke contains 39 grams of fructose and the USDA Recommended Daily Allowance allots for 32 grams of carbohydrates in a 2,000 calorie diet.<sup><a href="http://justthescience.com/archives/563#footnote_16_563" id="identifier_16_563" class="footnote-link footnote-identifier-link" title="Carbohydrates">17</a></sup>  A single 12 ounce Coke therefore contains significantly more than an individual&#8217;s entire excess dietary energy allowance for a day.  Raben <em>et al </em>2002 found that people have a very difficult time compensating for increased levels of calories associated with increased sugar intake by lowering caloric intake elsewhere.<sup><a href="http://justthescience.com/archives/563#footnote_17_563" id="identifier_17_563" class="footnote-link footnote-identifier-link" title="Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects">18</a></sup>  While moderate ingestion of HFCS will not specifically cause harm to oneself, it is advisable to monitor and limit consumption as much as possible.</p>
<ol class="footnotes"><li id="footnote_0_563" class="footnote"><a href="http://www.ajcn.cnfindpark.cn/cgi/content/abstract/79/4/537">Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity</a></li><li id="footnote_1_563" class="footnote"><a href="http://www.nutritionandmetabolism.com/content/2/1/5" target="_blank">Fructose, insulin resistance, and metabolic dyslipidemia</a></li><li id="footnote_2_563" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/76/5/911">Fructose, weight gain, and the insulin resistance syndrome</a></li><li id="footnote_3_563" class="footnote"><a href="http://www.ajcn.cnfindpark.cn/cgi/content/abstract/79/4/537">Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity</a></li><li id="footnote_4_563" class="footnote"><a href="http://jcem.endojournals.org/cgi/content/abstract/89/6/2963">Dietary Fructose Reduces Circulating Insulin and Leptin, Attenuates Postprandial Suppression of Ghrelin, and Increases Triglycerides in Women</a></li><li id="footnote_5_563" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/50/5/1008">Day-long glucose, insulin, and fructose responses of hyperinsulinemic and nonhyperinsulinemic men adapted to diets containing either fructose or high-amylose cornstarch</a></li><li id="footnote_6_563" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/86/6/1586">No differences in satiety or energy intake after high-fructose corn syrup, sucrose, or milk preloads</a></li><li id="footnote_7_563" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/88/6/1738S?ijkey=51a6eb2a2a2308a265762245d4dc6f538a555c36&amp;keytype2=tf_ipsecsha">High-fructose corn syrup, energy intake, and appetite regulation</a></li><li id="footnote_8_563" class="footnote"><a href="http://www.ajcn.cnfindpark.cn/cgi/content/abstract/86/5/1354">Effects of glucose-to-fructose ratios in solutions on subjective satiety, food intake, and satiety hormones in young men</a></li><li id="footnote_9_563" class="footnote"><a href="http://jn.nutrition.org/cgi/content/abstract/139/6/1242S">The Effect of High-Fructose Corn Syrup Consumption on Triglycerides and Uric Acid</a></li><li id="footnote_10_563" class="footnote"><a href="http://ajcn.cnfindpark.cn/cgi/content/abstract/87/5/1194">Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals</a></li><li id="footnote_11_563" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/17234503">Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women</a></li><li id="footnote_12_563" class="footnote"><a href="http://cat.inist.fr/?aModele=afficheN&amp;cpsidt=18373945">A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans</a></li><li id="footnote_13_563" class="footnote"><a href="http://www.ajcn.org/cgi/content/full/79/5/774?ijkey=cJSxz0rjkfs9s&amp;keytype=ref&amp;siteid=ajcn">Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment</a></li><li id="footnote_14_563" class="footnote"><a href="http://www.nutritionandmetabolism.com/content/2/1/5" target="_blank">Fructose, insulin resistance, and metabolic dyslipidemia</a></li><li id="footnote_15_563" class="footnote"><a href="http://www.nutritionandmetabolism.com/content/2/1/5#B7">Fructose, insulin resistance, and metabolic dyslipidemia</a></li><li id="footnote_16_563" class="footnote"><a href="http://www.health.gov/dietaryguidelines/dga2005/document/html/chapter7.htm" target="_blank">Carbohydrates</a></li><li id="footnote_17_563" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/12324283?dopt=Abstract&amp;holding=f1000,f1000m,isrctn">Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects</a></li></ol>]]></content:encoded>
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		<title>What causes kidney stones and can you prevent them?</title>
		<link>http://justthescience.com/archives/424</link>
		<comments>http://justthescience.com/archives/424#comments</comments>
		<pubDate>Thu, 15 Oct 2009 00:29:22 +0000</pubDate>
		<dc:creator></dc:creator>
				<category><![CDATA[Personal Health]]></category>
		<category><![CDATA[animal protein]]></category>
		<category><![CDATA[apple juice]]></category>
		<category><![CDATA[beer]]></category>
		<category><![CDATA[bimodal]]></category>
		<category><![CDATA[caffeinated coffee]]></category>
		<category><![CDATA[calcium compounds]]></category>
		<category><![CDATA[chronic diseases]]></category>
		<category><![CDATA[correlation]]></category>
		<category><![CDATA[decaffeinated coffee]]></category>
		<category><![CDATA[diet]]></category>
		<category><![CDATA[dietary calcium]]></category>
		<category><![CDATA[evolving consensus]]></category>
		<category><![CDATA[family history]]></category>
		<category><![CDATA[grapefruit juice]]></category>
		<category><![CDATA[Kidney Stones]]></category>
		<category><![CDATA[micro-bacteria]]></category>
		<category><![CDATA[phylate]]></category>
		<category><![CDATA[re-occurence]]></category>
		<category><![CDATA[sucrose]]></category>
		<category><![CDATA[supersaturation]]></category>
		<category><![CDATA[tea]]></category>
		<category><![CDATA[treatment resistant]]></category>
		<category><![CDATA[uric acid]]></category>
		<category><![CDATA[variance between sexes]]></category>
		<category><![CDATA[vitamin B6]]></category>
		<category><![CDATA[vitamin C]]></category>
		<category><![CDATA[vitamin D]]></category>
		<category><![CDATA[water intake]]></category>
		<category><![CDATA[weight]]></category>
		<category><![CDATA[wine]]></category>

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		<description><![CDATA[Kidney stones will effect around 5 percent of people in at some point in their life, and the rate is growing with time (Parmar 2004). 1   Significant variation of occurrence exists between sexes; men develop stones twice as often as women at an average age of 30 while for women average age is bimodal with peaks [...]]]></description>
			<content:encoded><![CDATA[<p>Kidney stones will effect around 5 percent of people in at some point in their life, and the rate is growing with time (Parmar 2004). <sup><a href="http://justthescience.com/archives/424#footnote_0_424" id="identifier_0_424" class="footnote-link footnote-identifier-link" title="Kidney stones">1</a></sup>   Significant variation of occurrence exists between sexes; men develop stones twice as often as women at an average age of 30 while for women average age is bimodal with peaks at 35 and 55 (Parmar 2004).<sup><a href="http://justthescience.com/archives/424#footnote_1_424" id="identifier_1_424" class="footnote-link footnote-identifier-link" title="Kidney stones">2</a></sup>   Once you have had one, you also have a very high chance of having another one as there is a re-occurrence rate of 50% over five years  (Borghi <em>et al</em> 1996).<sup><a href="http://justthescience.com/archives/424#footnote_2_424" id="identifier_2_424" class="footnote-link footnote-identifier-link" title="Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study">3</a></sup>  Although there is still somewhat of an evolving consensus around what the main cause is, literature points to treatment resistant micro-bacteria  (Çiftçioglu <em>et al</em> 1999) that combines with urine supersaturated with calcium compounds and uric acid (contributed by an individual&#8217;s diet), creating the kidney stone (Kajander <em>et al</em> 2003). <sup><a href="http://justthescience.com/archives/424#footnote_3_424" id="identifier_3_424" class="footnote-link footnote-identifier-link" title="Nanobacteria: An infectious cause for kidney stone formation">4</a></sup> <sup><a href="http://justthescience.com/archives/424#footnote_4_424" id="identifier_4_424" class="footnote-link footnote-identifier-link" title="Characteristics of nanobacteria and their possible role in stone formation">5</a></sup></p>
<p>An individual&#8217;s weight and family history have both been demonstrated to have a positive correlation with his or her risk of getting kidney stones (Taylor <em>et al</em> 2005) (Curhan <em>et al</em> 1997). <sup><a href="http://justthescience.com/archives/424#footnote_5_424" id="identifier_5_424" class="footnote-link footnote-identifier-link" title="Obesity, Weight Gain, and the Risk of Kidney Stones">6</a></sup> <sup><a href="http://justthescience.com/archives/424#footnote_6_424" id="identifier_6_424" class="footnote-link footnote-identifier-link" title="Family history and risk of kidney stones">7</a></sup>  However, lack of daily water intake has been demonstrated to be the greatest risk factor, and increasing one&#8217;s daily water intake is an easily preventative measure one can take to avoid getting stone&#8217;s in the first place (Borghi <em>et al</em> 1996). <sup><a href="http://justthescience.com/archives/424#footnote_7_424" id="identifier_7_424" class="footnote-link footnote-identifier-link" title="Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study">8</a></sup>  Drinking at least 2.5 liters of water per day has been shown to change the consistency of urine, lowering it&#8217;s saturation level of calcium compounds, thereby preventing supersaturation and it&#8217;s associated buildups (Borghi <em>et al</em> 1996).<sup><a href="http://justthescience.com/archives/424#footnote_8_424" id="identifier_8_424" class="footnote-link footnote-identifier-link" title="Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study">9</a></sup>  This alone has been found to reduce reoccurred rates of kidney stones from 50% to 20% over a five year period (Borghi <em>et al</em> 1996). <sup><a href="http://justthescience.com/archives/424#footnote_9_424" id="identifier_9_424" class="footnote-link footnote-identifier-link" title="Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study">10</a></sup></p>
<p>Intake of other fluids have also been found to decrease instances of kidney stones in both sexes.  A study by Curhan <em>et al</em> (1998) found the following percentage of occurrence reductions in women for each 240-mL (8-oz) daily serving of the following fluids: caffeinated coffee &#8211; 10%, decaffeinated coffee &#8211; 9%, tea &#8211; 8%, and wine &#8211; 59%.<sup><a href="http://justthescience.com/archives/424#footnote_10_424" id="identifier_10_424" class="footnote-link footnote-identifier-link" title="Beverage Use and Risk for Kidney Stones in Women">11</a></sup>  In contrast, a 44% increase in risk was seen for each 240-mL serving of grapefruit juice consumed daily (Curhan <em>et al</em> 1998).   In men the risk of stone formation decreased by the following percentages for each 240-ml (8-oz) daily serving of the following fluids:  caffeinated coffee 10%, decaffeinated coffee &#8211; 10%, tea &#8211; 14%,  beer &#8211; 21%, and wine &#8211; 39%. In contrast, a risk increased 35% for comparable servings of apple juice and 37% for grapefruit juice (Curhan <em>et al</em> 1996).<sup><a href="http://justthescience.com/archives/424#footnote_11_424" id="identifier_11_424" class="footnote-link footnote-identifier-link" title="Prospective Study of Beverage Use and the Risk of Kidney Stones">12</a></sup></p>
<p>Reducing one&#8217;s consumption of animal protein to less than 52g per day has also been shown to lower one&#8217;s risk of specific types of kidney stones (Breslau <em>et al</em> 1988).<sup><a href="http://justthescience.com/archives/424#footnote_12_424" id="identifier_12_424" class="footnote-link footnote-identifier-link" title="Relationship of Animal Protein-Rich Diet to Kidney Stone Formation and Calcium Metabolism">13</a></sup>  Increasing dietary calcium has been shown to lower risk for kidney stones in women (Borghi <em>et al</em> 2002) and men (Curhan <em>et al</em> 1993) and lowering your salt intake to less than 800 mg per day combined with lower intake of animal protein lowers men&#8217;s risk of re-occurrence by 18% (Borghi <em>et al 2002</em>).<sup><a href="http://justthescience.com/archives/424#footnote_13_424" id="identifier_13_424" class="footnote-link footnote-identifier-link" title="Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria">14</a></sup>  Also, vitamin B6 in doses of &gt;40mg/day has been found to reduce incidences of kidney stones in women (Curhan <em>et al</em> 1999).<sup><a href="http://justthescience.com/archives/424#footnote_14_424" id="identifier_14_424" class="footnote-link footnote-identifier-link" title="Intake of Vitamins B6 and C and the Risk of Kidney Stones in Women">15</a></sup><sup><a href="http://justthescience.com/archives/424#footnote_15_424" id="identifier_15_424" class="footnote-link footnote-identifier-link" title="A Prospective Study of Dietary Calcium and Other Nutrients and the Risk of Symptomatic Kidney Stones">16</a></sup>  A recent study by Taylor <em>et </em>al (2004) determined that in men: sodium phosphorus, sucrose, phytate, vitamin B6, vitamin D, and supplemental calcium were not independently associated with risk for first time instances, while magnesium intake decreases and total vitamin C intake seems to increase the risk of kidney stones (Taylor <em>et al</em> 2004).<sup><a href="http://justthescience.com/archives/424#footnote_16_424" id="identifier_16_424" class="footnote-link footnote-identifier-link" title="Dietary Factors and the Risk of Incident Kidney Stones in Men: New Insights after 14 Years of Follow-up">17</a></sup>  While this research may appear to contradict the previous study by Borghi <em>et al</em> (2002), this study examined the combination of reduced salt and animal protein, which suggests that reducing animal protein consumption is a more important dietary change to aid in reduced kidney stone risk.<sup><a href="http://justthescience.com/archives/424#footnote_17_424" id="identifier_17_424" class="footnote-link footnote-identifier-link" title="Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria">18</a></sup></p>
<ol class="footnotes"><li id="footnote_0_424" class="footnote"><a href="http://www.bmj.com/cgi/content/full/328/7453/1420?etoc#REF2">Kidney stones</a></li><li id="footnote_1_424" class="footnote"><a href="http://www.bmj.com/cgi/content/full/328/7453/1420?etoc#REF2">Kidney stones</a></li><li id="footnote_2_424" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/8583588?dopt=Abstract">Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study</a></li><li id="footnote_3_424" class="footnote"><a href="http://www.nature.com/ki/journal/v56/n5/abs/4491112a.html">Nanobacteria: An infectious cause for kidney stone formation</a></li><li id="footnote_4_424" class="footnote"><a href="http://www.springerlink.com/content/5kch22gexykuqbln/">Characteristics of nanobacteria and their possible role in stone formation</a></li><li id="footnote_5_424" class="footnote"><a href="http://jama.ama-assn.org/cgi/content/abstract/293/4/455">Obesity, Weight Gain, and the Risk of Kidney Stones</a></li><li id="footnote_6_424" class="footnote"><a href="http://jasn.asnjournals.org/cgi/content/abstract/8/10/1568">Family history and risk of kidney stones</a></li><li id="footnote_7_424" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/8583588?dopt=Abstract">Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study</a></li><li id="footnote_8_424" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/8583588?dopt=Abstract">Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study</a></li><li id="footnote_9_424" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/8583588?dopt=Abstract">Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study</a></li><li id="footnote_10_424" class="footnote"><a href="http://www.annals.org/cgi/content/abstract/128/7/534">Beverage Use and Risk for Kidney Stones in Women</a></li><li id="footnote_11_424" class="footnote"><a href="http://aje.oxfordjournals.org/cgi/content/abstract/143/3/240">Prospective Study of Beverage Use and the Risk of Kidney Stones</a></li><li id="footnote_12_424" class="footnote"><a href="http://jcem.endojournals.org/cgi/content/abstract/66/1/140">Relationship of Animal Protein-Rich Diet to Kidney Stone Formation and Calcium Metabolism</a></li><li id="footnote_13_424" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/11784873?dopt=Abstract" target="_blank">Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria</a></li><li id="footnote_14_424" class="footnote"><a href="http://jasn.asnjournals.org/cgi/content/abstract/10/4/840">Intake of Vitamins B6 and C and the Risk of Kidney Stones in Women</a></li><li id="footnote_15_424" class="footnote"><a href="http://content.nejm.org/cgi/content/abstract/328/12/833">A Prospective Study of Dietary Calcium and Other Nutrients and the Risk of Symptomatic Kidney Stones</a></li><li id="footnote_16_424" class="footnote"><a href="http://jasn.asnjournals.org/cgi/content/abstract/15/12/3225">Dietary Factors and the Risk of Incident Kidney Stones in Men: New Insights after 14 Years of Follow-up</a></li><li id="footnote_17_424" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/11784873?dopt=Abstract" target="_blank">Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria</a></li></ol>]]></content:encoded>
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		<title>What are the effects of using energy drinks?</title>
		<link>http://justthescience.com/archives/387</link>
		<comments>http://justthescience.com/archives/387#comments</comments>
		<pubDate>Tue, 13 Oct 2009 00:36:15 +0000</pubDate>
		<dc:creator></dc:creator>
				<category><![CDATA[Personal Health]]></category>
		<category><![CDATA[abstract thinking]]></category>
		<category><![CDATA[aerobic endurance]]></category>
		<category><![CDATA[anaerobic performance]]></category>
		<category><![CDATA[bile salt formation]]></category>
		<category><![CDATA[caffeine]]></category>
		<category><![CDATA[cerebellum]]></category>
		<category><![CDATA[choice reaction time]]></category>
		<category><![CDATA[cognitive function]]></category>
		<category><![CDATA[Coke]]></category>
		<category><![CDATA[concentration]]></category>
		<category><![CDATA[dental enamel]]></category>
		<category><![CDATA[diabetes mellitus]]></category>
		<category><![CDATA[energy]]></category>
		<category><![CDATA[energy drinks]]></category>
		<category><![CDATA[epinephrine]]></category>
		<category><![CDATA[extract]]></category>
		<category><![CDATA[free amino acid]]></category>
		<category><![CDATA[ginseng]]></category>
		<category><![CDATA[guarana]]></category>
		<category><![CDATA[herpes simplex type-II infection]]></category>
		<category><![CDATA[hypertension]]></category>
		<category><![CDATA[immunmodulation]]></category>
		<category><![CDATA[immunomodulation]]></category>
		<category><![CDATA[memory]]></category>
		<category><![CDATA[norepinephrine]]></category>
		<category><![CDATA[osmoregulation]]></category>
		<category><![CDATA[physical performance]]></category>
		<category><![CDATA[physiologically effective]]></category>
		<category><![CDATA[Placebo]]></category>
		<category><![CDATA[psychomotor performance]]></category>
		<category><![CDATA[secondary memory]]></category>
		<category><![CDATA[simple reaction performance]]></category>
		<category><![CDATA[speed of attention]]></category>
		<category><![CDATA[sugar]]></category>
		<category><![CDATA[synergistic relationship]]></category>
		<category><![CDATA[taurine]]></category>

		<guid isPermaLink="false">http://justthescience.com/?p=387</guid>
		<description><![CDATA[Energy drinks are a common way for individuals to presumably increase their energy level.&#160; In addition, more and more varieties of energy drinks with various ingredients are constantly appearing, all claiming to be the most effective.&#160; We intend to examine whether or not energy drinks are really physiologically effective, what ingredients increase energy levels most [...]]]></description>
			<content:encoded><![CDATA[<p>Energy drinks are a common way for individuals to presumably increase their energy level.&nbsp; In addition, more and more varieties of energy drinks with various ingredients are constantly appearing, all claiming to be the most effective.&nbsp; We intend to examine whether or not energy drinks are really physiologically effective, what ingredients increase energy levels most effectively, and whether or not there are any possibly harmful side effects.</p>
<p>A study by Alford <em>et al</em> (2001) found that the intake of energy drinks is correlated with improved aerobic endurance and anaerobic performance, as well as significant improvements in choice reaction time, concentration, and memory.<sup><a href="http://justthescience.com/archives/387#footnote_0_387" id="identifier_0_387" class="footnote-link footnote-identifier-link" title="The effects of Red Bull Energy Drink on human performance and mood">1</a></sup> Horne and Reyner (2001) found that energy drinks significantly improved the reaction time and reduced lane drifting of sleepy individuals when compared to a placebo, with the greatest improvement lasting an hour after ingestion.<sup><a href="http://justthescience.com/archives/387#footnote_1_387" id="identifier_1_387" class="footnote-link footnote-identifier-link" title="Beneficial effects of an &amp;#8220;energy drink&amp;#8221; given to sleepy drivers">2</a></sup> Scholey and Kennedy (2004) determined that the combination of caffeine and sugar found in most energy drinks have a possibly synergistic relationship which results in improved secondary memory and speed of attention.<sup><a href="http://justthescience.com/archives/387#footnote_2_387" id="identifier_2_387" class="footnote-link footnote-identifier-link" title="Cognitive and physiological effects of an &ldquo;energy drink&rdquo;: an evaluation of the whole drink and of glucose, caffeine and herbal flavouring fractions">3</a></sup></p>
<p>Since it has been demonstrated that energy drinks do have a physiological effect on the body, it&#8217;s important to investigate which ingredients are contributing to this effect.&nbsp; The most common ingredients found in energy drinks are: sugar, caffeine, taurine, guarana, and ginseng.&nbsp; Studies on taurine&#8217;s impact on the body are predominantly inconclusive (Triebel <em>et al</em> 2006), although it has been noted that this free amino acid may play an important role in osmoregulation, immunomodulation, and bile salt formation (Bouckenooghe <em>et al</em> 2006), and consuming energy drinks with taurine increases taurine levels in the cerebellum (Roser <em>et al</em> 1998).&nbsp;<sup><a href="http://justthescience.com/archives/387#footnote_3_387" id="identifier_3_387" class="footnote-link footnote-identifier-link" title="Is taurine a functional nutrient?">4</a></sup>&nbsp;<sup><a href="http://justthescience.com/archives/387#footnote_4_387" id="identifier_4_387" class="footnote-link footnote-identifier-link" title="Rapid analysis of taurine in energy drinks using amino acid analyzer and Fourier transform infrared (FTIR) spectroscopy as basis for toxicological evaluation">5</a></sup>&nbsp;<sup><a href="http://justthescience.com/archives/387#footnote_5_387" id="identifier_5_387" class="footnote-link footnote-identifier-link" title="Dangerous Increase of Taurine in the Human Brain after Consumption of an &amp;#8216;Energy Drink&amp;#8217;?">6</a></sup>&nbsp; A separate study by Geiß <em>et al</em> (1994) found that energy drinks with taurine led to lower sustained levels of the hormones epinephrine and norepinephrine, which led to significantly longer endurance times in cyclists.<sup><a href="http://justthescience.com/archives/387#footnote_6_387" id="identifier_6_387" class="footnote-link footnote-identifier-link" title="The effect of a taurine-containing drink on performance in 10 endurance-athletes">7</a></sup>&nbsp; Guarana and ginseng extract are believed to be stimulants that affect cognition (Kennedy <em>et al</em> 2004).&nbsp;<sup><a href="http://justthescience.com/archives/387#footnote_7_387" id="identifier_7_387" class="footnote-link footnote-identifier-link" title="Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng">8</a></sup>&nbsp; A study by Haskell <em>et al</em> 2007 determined that Guarana improves memory and general attentiveness,<sup><a href="http://justthescience.com/archives/387#footnote_8_387" id="identifier_8_387" class="footnote-link footnote-identifier-link" title="A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guaran&aacute; in humans">9</a></sup> and Sorensen and Sonne (1996) reported that ginseng improved simple reaction performance as well as abstract thinking.&nbsp; Other studies have found ginseng supplementation has no effect on physical performance, psychomotor performance and cognitive function, immunmodulation, diabetes mellitus and herpes simplex type-II infection (Engels and Wirth 1997) (Vogler <em>et al </em>1999) (Persson <em>et al</em> 2003).&nbsp;<sup><a href="http://justthescience.com/archives/387#footnote_9_387" id="identifier_9_387" class="footnote-link footnote-identifier-link" title="No ergogenic effects of ginseng (Panax ginseng C.A. Meyer) during graded maximal aerobic exercise">10</a></sup>&nbsp;<sup><a href="http://justthescience.com/archives/387#footnote_10_387" id="identifier_10_387" class="footnote-link footnote-identifier-link" title="A double-masked study of the effects of ginseng on cognitive functions">11</a></sup>&nbsp;<sup><a href="http://justthescience.com/archives/387#footnote_11_387" id="identifier_11_387" class="footnote-link footnote-identifier-link" title="The memory-enhancing effects of Ginseng and Ginkgo biloba in healthy volunteers">12</a></sup>&nbsp;<sup><a href="http://justthescience.com/archives/387#footnote_12_387" id="identifier_12_387" class="footnote-link footnote-identifier-link" title="The efficacy of ginseng. A systematic review of randomised clinical trials">13</a></sup></p>
<p>Despite all of the alleged beneficial properties of including the aforementioned ingredients in energy drinks, a study by Clauson <em>et al</em> (2008) found that popular energy drinks do not have high enough levels of Guarana, Taurine, or Ginseng to have any beneficial physiological or psychological effects, and that the only ingredients in high enough concentrations to have effects are caffeine and sugar (Clauson <em>et al</em> 2008).&nbsp;<sup><a href="http://justthescience.com/archives/387#footnote_13_387" id="identifier_13_387" class="footnote-link footnote-identifier-link" title="Safety issues associated with commercially available energy drinks">14</a></sup>&nbsp; Caffeine levels in energy drinks can range from 0mg per serving to 141.1mg which is almost a three fold increase over Coke which contains ~44.5mg per serving (McCusker <em>et al</em> 2006).<sup><a href="http://justthescience.com/archives/387#footnote_14_387" id="identifier_14_387" class="footnote-link footnote-identifier-link" title="TECHNICAL NOTE: Caffeine Content of Energy Drinks, Carbonated Sodas, and Other Beverages">15</a></sup>&nbsp; Additionally, Candow <em>et </em><span style="font-style: italic;">al</span> 2009 found no improvement in physical endurance as a result of sugar free energy drinks.<sup><a href="http://justthescience.com/archives/387#footnote_15_387" id="identifier_15_387" class="footnote-link footnote-identifier-link" title="Effect of Sugar-Free Red Bull Energy Drink on High-Intensity Run Time-to-Exhaustion in Young Adults">16</a></sup></p>
<p>While the research around caffeine and sugar intakes will require articles of their own, some studies have been done regarding the risks of energy drinks themselves.&nbsp; Aside from the high level of sugar in energy drinks which could contribute to diabetes, studies have shown that people who have had prior psychiatric issues should avoid energy drinks as it may cause a relapse (Chelben <em>et al</em> 2008) and that the drinks have significant erosive effects on dental enamel (Kitchens <em>et al</em> 2007).<sup><a href="http://justthescience.com/archives/387#footnote_16_387" id="identifier_16_387" class="footnote-link footnote-identifier-link" title="Effects of amino acid energy drinks leading to hospitalization in individuals with mental illness">17</a></sup>&nbsp;<sup><a href="http://justthescience.com/archives/387#footnote_17_387" id="identifier_17_387" class="footnote-link footnote-identifier-link" title="Effect of Carbonated Beverages, Coffee, Sports and High Energy Drinks, and Bottled Water on the in vitro Erosion Characteristics of Dental Enamel">18</a></sup>&nbsp; The effects of energy drinks and hypertension has had conflicting research and is as of this writing, unresolved (Hirata <em>et al</em> 2003) (Winkelmayer <em>et al </em>2005).<sup><a href="http://justthescience.com/archives/387#footnote_18_387" id="identifier_18_387" class="footnote-link footnote-identifier-link" title="Caffeine increases aortic stiffness in hypertensive patients">19</a></sup>&nbsp;<sup><a href="http://justthescience.com/archives/387#footnote_19_387" id="identifier_19_387" class="footnote-link footnote-identifier-link" title="Habitual Caffeine Intake and the Risk of Hypertension in Women">20</a></sup></p>
<ol class="footnotes"><li id="footnote_0_387" class="footnote"><a href="http://www.springerlink.com/content/xxdbgvjy9ke72wbl/">The effects of Red Bull Energy Drink on human performance and mood</a></li><li id="footnote_1_387" class="footnote"><a href="http://www.springerlink.com/content/8t8x100htaacpxck/">Beneficial effects of an &#8220;energy drink&#8221; given to sleepy drivers</a></li><li id="footnote_2_387" class="footnote"><a href="http://www.springerlink.com/content/hh6mllfq03fycq9p/">Cognitive and physiological effects of an “energy drink”: an evaluation of the whole drink and of glucose, caffeine and herbal flavouring fractions</a></li><li id="footnote_3_387" class="footnote"><a href="http://journals.lww.com/co-clinicalnutrition/Abstract/2006/11000/Is_taurine_a_functional_nutrient_.13.aspx" target="_blank">Is taurine a functional nutrient?</a></li><li id="footnote_4_387" class="footnote"><a href="http://www.springerlink.com/content/j0173j005x857167/">Rapid analysis of taurine in energy drinks using amino acid analyzer and Fourier transform infrared (FTIR) spectroscopy as basis for toxicological evaluation</a></li><li id="footnote_5_387" class="footnote"><a href="http://cds.ismrm.org/ismrm-1998/PDF7/P1886.PDF">Dangerous Increase of Taurine in the Human Brain after Consumption of an &#8216;Energy Drink&#8217;?</a></li><li id="footnote_6_387" class="footnote"><a href="http://www.springerlink.com/content/j0173j005x857167/">The effect of a taurine-containing drink on performance in 10 endurance-athletes</a></li><li id="footnote_7_387" class="footnote"><a href="http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6T0N-4DR03CG-2&amp;_user=10&amp;_rdoc=1&amp;_fmt=&amp;_orig=search&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_searchStrId=1041771829&amp;_rerunOrigin=scholar.google&amp;_acct=C000050221&amp;_version=1&amp;_urlVersion=0&amp;_userid=10&amp;md5=d734f4bb24e7612c97ba768a9e7a1402" target="_blank">Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng</a></li><li id="footnote_8_387" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/16533867">A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guaraná in humans</a></li><li id="footnote_9_387" class="footnote"><a href="http://grande.nal.usda.gov/ibids/index.php?mode2=detail&amp;origin=ibids_references&amp;therow=48374" target="_blank">No ergogenic effects of ginseng (Panax ginseng C.A. Meyer) during graded maximal aerobic exercise</a></li><li id="footnote_10_387" class="footnote"><a href="http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6VS8-445RB6T-DF&amp;_user=10&amp;_rdoc=1&amp;_fmt=&amp;_orig=search&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_searchStrId=1041784488&amp;_rerunOrigin=scholar.google&amp;_acct=C000050221&amp;_version=1&amp;_urlVersion=0&amp;_userid=10&amp;md5=f44f0303e7ce3c1c1bbb4cb086e4dd40" target="_blank">A double-masked study of the effects of ginseng on cognitive functions</a></li><li id="footnote_11_387" class="footnote"><a href="http://www.springerlink.com/content/lheb14v2aj1uy2ah/" target="_blank">The memory-enhancing effects of Ginseng and Ginkgo biloba in healthy volunteers</a></li><li id="footnote_12_387" class="footnote"><a href="http://www.springerlink.com/content/wbw9aqkcx9qg4kcy/" target="_blank">The efficacy of ginseng. A systematic review of randomised clinical trials</a></li><li id="footnote_13_387" class="footnote"><a href="http://japha.metapress.com/app/home/contribution.asp?referrer=parent&amp;backto=issue,1,20;journal,11,43;linkingpublicationresults,1:120082,1">Safety issues associated with commercially available energy drinks</a></li><li id="footnote_14_387" class="footnote"><a href="http://www.ingentaconnect.com/content/pres/jat/2006/00000030/00000002/art00008" target="_blank">TECHNICAL NOTE: Caffeine Content of Energy Drinks, Carbonated Sodas, and Other Beverages</a></li><li id="footnote_15_387" class="footnote"><a href="http://journals.lww.com/nsca-jscr/Abstract/2009/07000/Effect_of_Sugar_Free_Red_Bull_Energy_Drink_on.31.aspx">Effect of Sugar-Free Red Bull Energy Drink on High-Intensity Run Time-to-Exhaustion in Young Adults</a></li><li id="footnote_16_387" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/18291302">Effects of amino acid energy drinks leading to hospitalization in individuals with mental illness</a></li><li id="footnote_17_387" class="footnote"><a href="http://pediatricdentistry.metapress.com/content/1157l653t8206100/">Effect of Carbonated Beverages, Coffee, Sports and High Energy Drinks, and Bottled Water on the in vitro Erosion Characteristics of Dental Enamel</a></li><li id="footnote_18_387" class="footnote"><a href="http://journals.indexcopernicus.com/abstracted.php?icid=568859" target="_blank">Caffeine increases aortic stiffness in hypertensive patients</a></li><li id="footnote_19_387" class="footnote"><a href="http://jama.ama-assn.org/cgi/content/abstract/294/18/2330" target="_blank">Habitual Caffeine Intake and the Risk of Hypertension in Women</a></li></ol>]]></content:encoded>
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		<title>Is taking a daily multivitamin beneficial?</title>
		<link>http://justthescience.com/archives/266</link>
		<comments>http://justthescience.com/archives/266#comments</comments>
		<pubDate>Tue, 06 Oct 2009 22:45:33 +0000</pubDate>
		<dc:creator></dc:creator>
				<category><![CDATA[Personal Health]]></category>
		<category><![CDATA[adolescents]]></category>
		<category><![CDATA[birth defects]]></category>
		<category><![CDATA[bone density]]></category>
		<category><![CDATA[cancer]]></category>
		<category><![CDATA[cardiovascular disease]]></category>
		<category><![CDATA[dietary supplement]]></category>
		<category><![CDATA[heart disease]]></category>
		<category><![CDATA[immune system]]></category>
		<category><![CDATA[micronutrients]]></category>
		<category><![CDATA[multivitamins]]></category>
		<category><![CDATA[pregnancy]]></category>

		<guid isPermaLink="false">http://justthescience.com/?p=266</guid>
		<description><![CDATA[A study by Garland et al (2005) demonstrated that it is difficult for adults in America to get consistently adequate levels of micronutrients, especially those that come from more unconventional sources (i.e. Vitamin D, which comes from sunlight).1  Several studies have determined specific demographics that are particularly susceptible to micronutrient deficiencies, including:  women of child [...]]]></description>
			<content:encoded><![CDATA[<p>A study by Garland <em>et al</em> (2005) demonstrated that it is difficult for adults in America to get consistently adequate levels of micronutrients, especially those that come from more unconventional sources (i.e. Vitamin D, which comes from sunlight).<sup><a href="http://justthescience.com/archives/266#footnote_0_266" id="identifier_0_266" class="footnote-link footnote-identifier-link" title="Do sunlight and vitamin D reduce the likelihood of colon cancer?">1</a></sup>  Several studies have determined specific demographics that are particularly susceptible to micronutrient deficiencies, including:  women of child bearing age who may become pregnant  (Olshan <em>et al</em> 2002),<sup><a href="http://justthescience.com/archives/266#footnote_1_266" id="identifier_1_266" class="footnote-link footnote-identifier-link" title="Maternal Vitamin Use and Reduced Risk of Neuroblastoma">2</a></sup> people with deficiency inducing diseases such as type 2 diabetes (Barringer <em>et al </em>2003),<sup><a href="http://justthescience.com/archives/266#footnote_2_266" id="identifier_2_266" class="footnote-link footnote-identifier-link" title="Effect of a Multivitamin and Mineral Supplement on Infection and Quality of Life">3</a></sup> 40% of people over age 65  (Chandra 2001),<sup><a href="http://justthescience.com/archives/266#footnote_3_266" id="identifier_3_266" class="footnote-link footnote-identifier-link" title="Effect of Vitamin and Trace-Element Supplementation on Cognitive Function in Elderly Subjects">4</a></sup> 50% of postmenopausal women (Holick <em>et al</em> 2005), <sup><a href="http://justthescience.com/archives/266#footnote_4_266" id="identifier_4_266" class="footnote-link footnote-identifier-link" title="Prevalence of Vitamin D Inadequacy among Postmenopausal North American Women Receiving Osteoporosis Therapy">5</a></sup> and 100% of adolescents (Stang <em>et al</em> (2000)<sup><a href="http://justthescience.com/archives/266#footnote_5_266" id="identifier_5_266" class="footnote-link footnote-identifier-link" title="Relationships between vitamin and mineral supplement use dietary intake and dietary adequacy among adolescents">6</a></sup>.  A common dietary supplement for these demographics, and those concerned about their daily intake of essential micronutrients are multivitamins.  Extensive research has been conducted on the validity of this practice, with a major concern being whether multivitamins are as effective in delivering their content as natural sources.  Earnest <em>et al</em> (2003) found that intake of multivitamins did in fact increase overall vitamin levels by studying the levels of vitamins B6, B12, and folic acid over the course of 24 week period and a study by Navarro <em>et al</em> (2003) found that the multivitamin disintegration properties due to physical make up (whole tablet, crushed tablet, powder) did not affect the delivery efficacy of micronutrients, and that multivitamins are an effective mechanism of micronutrient delivery. <sup><a href="http://justthescience.com/archives/266#footnote_6_266" id="identifier_6_266" class="footnote-link footnote-identifier-link" title="Plasma Changes in Micronutrients Following a Multivitamin and Mineral Supplement in Healthy Adults">7</a></sup> <sup><a href="http://justthescience.com/archives/266#footnote_7_266" id="identifier_7_266" class="footnote-link footnote-identifier-link" title="Efficacy of a complex multivitamin supplement">8</a></sup></p>
<p>Numerous studies have found correlations between taking daily multivitamins and a number of health benefits. These include: increased cognitive functions in the elderly (Chandra 2001), <sup><a href="http://justthescience.com/archives/266#footnote_8_266" id="identifier_8_266" class="footnote-link footnote-identifier-link" title="Effect of Vitamin and Trace-Element Supplementation on Cognitive Function in Elderly Subjects">9</a></sup> lower instances of colorectal cancer (Jacobs <em>et al</em> 2003),<sup><a href="http://justthescience.com/archives/266#footnote_9_266" id="identifier_9_266" class="footnote-link footnote-identifier-link" title="Multivitamin Use and Colorectal Cancer Incidence in a US Cohort: Does Timing Matter?">10</a></sup> lower instances of heart disease (Holmquist <em>et al </em>2003), <sup><a href="http://justthescience.com/archives/266#footnote_10_266" id="identifier_10_266" class="footnote-link footnote-identifier-link" title="Multivitamin Supplements Are Inversely Associated with Risk of Myocardial Infarction in Men and Women">11</a></sup> improved immune system in people over 59 years of age (Bogden <em>et al</em> 1994), <sup><a href="http://justthescience.com/archives/266#footnote_11_266" id="identifier_11_266" class="footnote-link footnote-identifier-link" title="Daily micronutrient supplements enhance delayed-hypersensitivity skin test responses in older people">12</a></sup> and increased in bone density in postmenopausal women (Morton <em>et al</em> 2001).<sup><a href="http://justthescience.com/archives/266#footnote_12_266" id="identifier_12_266" class="footnote-link footnote-identifier-link" title="Vitamin C Supplement Use and Bone Mineral Density in Postmenopausal Women">13</a></sup>  Separate studies have determined multivitamin intake during pregnancy decreased levels of childhood cancers (Olshan <em>et al</em> 2002) <sup><a href="http://justthescience.com/archives/266#footnote_13_266" id="identifier_13_266" class="footnote-link footnote-identifier-link" title="Maternal Vitamin Use and Reduced Risk of Neuroblastoma">14</a></sup>, lowers instances of birth defects (Botto <em>et al</em> 2004),<sup><a href="http://justthescience.com/archives/266#footnote_14_266" id="identifier_14_266" class="footnote-link footnote-identifier-link" title="Vitamin Supplements and the Risk for Congenital Anomalies Other Than Neural Tube Defects">15</a></sup> and lowers instances of childhood anemia (Geltman <em>et al </em>2004).<sup><a href="http://justthescience.com/archives/266#footnote_15_266" id="identifier_15_266" class="footnote-link footnote-identifier-link" title="Daily Multivitamins With Iron to Prevent Anemia in High-Risk Infants: A Randomized Clinical Trial">16</a></sup></p>
<p>It is important to note that excess ingestion of all vitamins is not beneficial.  In some instances, vitamin intake above a certain level will have no effect.  For example, Levin <em>et al</em> (1996) found that doses of Vitamin C over 400 mg per day had no physiological effect, and any amount over 1,000 mg is simply excreted not utilized.<sup><a href="http://justthescience.com/archives/266#footnote_16_266" id="identifier_16_266" class="footnote-link footnote-identifier-link" title="Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance">17</a></sup>  In other instances, overdosage can be detrimental.  A study by Graat <em>et al</em> (2002) found that taking Vitamin E in supplement form worsens acute respiratory tract infections in well nourished people over the age of 60,<sup><a href="http://justthescience.com/archives/266#footnote_17_266" id="identifier_17_266" class="footnote-link footnote-identifier-link" title="Effect of Daily Vitamin E and Multivitamin-Mineral Supplementation on Acute Respiratory Tract Infections in Elderly Persons">18</a></sup> and Omenn <em>et al </em>(1996) found correlations between taking Vitamin A in supplement form and increased lung cancer rates and cardiovascular disease in smokers.<sup><a href="http://justthescience.com/archives/266#footnote_18_266" id="identifier_18_266" class="footnote-link footnote-identifier-link" title="Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease">19</a></sup>  Wooltorton (2003) examined micronutrient overdosage effects that exist for all individuals, and found: overdosage of magnesium and phosphorus can cause diarrhea;  overdosage of iron can cause constipation, nausea, vomiting, and reduced zinc uptake; overdosage of zinc can cause nausea, vomiting, immunosuppression, and impaired copper uptake; and overdsoage of selenium can cause brittle hair and nails, peripheral neuropathies, and gastrointestinal upset.<sup><a href="http://justthescience.com/archives/266#footnote_19_266" id="identifier_19_266" class="footnote-link footnote-identifier-link" title="Too much of a good thing? Toxic effects of vitamin and mineral supplements">20</a></sup>  A study by Lawson <em>et al</em> (2007) found that high doses of multivitamins correlates with increased levels of advanced and fatal prostate cancer.<sup><a href="http://justthescience.com/archives/266#footnote_20_266" id="identifier_20_266" class="footnote-link footnote-identifier-link" title="Multivitamin Use and Risk of Prostate Cancer in the National Institutes of Health&ndash;AARP Diet and Health Study">21</a></sup></p>
<p>Based on these studies, it is reasonable to state that multivitamins are a beneficial supplement to one&#8217;s daily diet, provided that a recommended dosage is taken. If one feels they are in a demographic that could be affected negatively by this supplementation, contact a physician before starting.</p>
<ol class="footnotes"><li id="footnote_0_266" class="footnote"><a href="http://ije.oxfordjournals.org/cgi/content/full/35/2/217">Do sunlight and vitamin D reduce the likelihood of colon cancer?</a></li><li id="footnote_1_266" class="footnote"><a href="http://www.jstor.org/pss/3703942">Maternal Vitamin Use and Reduced Risk of Neuroblastoma</a></li><li id="footnote_2_266" class="footnote"><a href="http://www.annals.org/cgi/content/abstract/138/5/365">Effect of a Multivitamin and Mineral Supplement on Infection and Quality of Life</a></li><li id="footnote_3_266" class="footnote"><a href="http://www.sethroberts.net/chandra/Effect_of_Vitamin_and_Trace_Element_Supplementation_on_Cognitive_Function_in_Elderly_Subjects.pdf">Effect of Vitamin and Trace-Element Supplementation on Cognitive Function in Elderly Subjects</a></li><li id="footnote_4_266" class="footnote"><a href="http://jcem.endojournals.org/cgi/content/abstract/90/6/3215">Prevalence of Vitamin D Inadequacy among Postmenopausal North American Women Receiving Osteoporosis Therapy</a></li><li id="footnote_5_266" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/10955048">Relationships between vitamin and mineral supplement use dietary intake and dietary adequacy among adolescents</a></li><li id="footnote_6_266" class="footnote"><a href="http://www.jacn.org/cgi/content/abstract/22/2/124">Plasma Changes in Micronutrients Following a Multivitamin and Mineral Supplement in Healthy Adults</a></li><li id="footnote_7_266" class="footnote"><a href="http://www.journals.elsevierhealth.com/periodicals/nut/article/PIIS0899900702008080/abstract" target="_blank">Efficacy of a complex multivitamin supplement</a></li><li id="footnote_8_266" class="footnote"><a href="http://www.sethroberts.net/chandra/Effect_of_Vitamin_and_Trace_Element_Supplementation_on_Cognitive_Function_in_Elderly_Subjects.pdf">Effect of Vitamin and Trace-Element Supplementation on Cognitive Function in Elderly Subjects</a></li><li id="footnote_9_266" class="footnote"><a href="http://aje.oxfordjournals.org/cgi/content/abstract/158/7/621">Multivitamin Use and Colorectal Cancer Incidence in a US Cohort: Does Timing Matter?</a></li><li id="footnote_10_266" class="footnote"><a href="http://jn.nutrition.org/cgi/content/full/133/8/2650">Multivitamin Supplements Are Inversely Associated with Risk of Myocardial Infarction in Men and Women</a></li><li id="footnote_11_266" class="footnote"><a href="http://www.ajcn.org/cgi/content/abstract/60/3/437">Daily micronutrient supplements enhance delayed-hypersensitivity skin test responses in older people</a></li><li id="footnote_12_266" class="footnote"><a href="http://www.jbmronline.org/doi/full/10.1359/jbmr.2001.16.1.135?cookieSet=1">Vitamin C Supplement Use and Bone Mineral Density in Postmenopausal Women</a></li><li id="footnote_13_266" class="footnote"><a href="http://www.jstor.org/pss/3703942">Maternal Vitamin Use and Reduced Risk of Neuroblastoma</a></li><li id="footnote_14_266" class="footnote"><a href="http://www.nutritionetgrossesse.org/pdf/botto2004.pdf">Vitamin Supplements and the Risk for Congenital Anomalies Other Than Neural Tube Defects</a></li><li id="footnote_15_266" class="footnote"><a href="http://pediatrics.aappublications.org/cgi/content/abstract/114/1/86">Daily Multivitamins With Iron to Prevent Anemia in High-Risk Infants: A Randomized Clinical Trial</a></li><li id="footnote_16_266" class="footnote"><a href="http://www.pnas.org/content/93/8/3704.abstract" target="_blank">Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance</a></li><li id="footnote_17_266" class="footnote"><a href="http://jama.ama-assn.org/cgi/content/abstract/288/6/715">Effect of Daily Vitamin E and Multivitamin-Mineral Supplementation on Acute Respiratory Tract Infections in Elderly Persons</a></li><li id="footnote_18_266" class="footnote"><a href="http://content.nejm.org/cgi/content/abstract/334/18/1150">Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease</a></li><li id="footnote_19_266" class="footnote"><a href="http://www.cmaj.ca/cgi/content/full/169/1/47#T127">Too much of a good thing? Toxic effects of vitamin and mineral supplements</a></li><li id="footnote_20_266" class="footnote"><a href="http://jnci.oxfordjournals.org/cgi/content/full/99/10/754?ijkey=f3e7a99dc4905085b3f678e704b342c7a92e7153">Multivitamin Use and Risk of Prostate Cancer in the National Institutes of Health–AARP Diet and Health Study</a></li></ol>]]></content:encoded>
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		<title>Are amalgam fillings harmful?</title>
		<link>http://justthescience.com/archives/106</link>
		<comments>http://justthescience.com/archives/106#comments</comments>
		<pubDate>Thu, 01 Oct 2009 19:42:30 +0000</pubDate>
		<dc:creator></dc:creator>
				<category><![CDATA[Personal Health]]></category>
		<category><![CDATA[Alzheimer's]]></category>
		<category><![CDATA[Amalgam]]></category>
		<category><![CDATA[chronic diseases]]></category>
		<category><![CDATA[chronic fatigue syndrome]]></category>
		<category><![CDATA[Mercury]]></category>
		<category><![CDATA[Multiple Sclerosis]]></category>
		<category><![CDATA[Parkinson's]]></category>
		<category><![CDATA[Placebo]]></category>
		<category><![CDATA[renal toxicity]]></category>
		<category><![CDATA[reproductive disorders]]></category>
		<category><![CDATA[Toxicity]]></category>

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		<description><![CDATA[Amalgam fillings, commonly used for the last century, are an alloy of approximately 50% mercury, 35% silver with other trace elements (Hahn et al 1989)1.  Mercury is a versatile element, and is utilized in both organic and inorganic forms; both of which are toxic (Langford and Ferner 1999).2 A study by Nylander et al (1987) [...]]]></description>
			<content:encoded><![CDATA[<p>Amalgam fillings, commonly used for the last century, are an alloy of approximately 50% mercury, 35% silver with other trace elements (Hahn <em>et al</em> 1989)<sup><a href="http://justthescience.com/archives/106#footnote_0_106" id="identifier_0_106" class="footnote-link footnote-identifier-link" title="Dental &amp;#8220;silver&amp;#8221; tooth fillings: a source of mercury exposure revealed by whole-body image scan and tissue analysis">1</a></sup>.  Mercury is a versatile element, and is utilized in both organic and inorganic forms; both of which are toxic (Langford and Ferner 1999).<sup><a href="http://justthescience.com/archives/106#footnote_1_106" id="identifier_1_106" class="footnote-link footnote-identifier-link" title="Toxicity of mercury">2</a></sup> A study by Nylander <em>et al</em> (1987) demonstrated a statistical correlation between number of amalgam fillings  and amount of accumulated inorganic mercury in an individuals body. <sup><a href="http://justthescience.com/archives/106#footnote_2_106" id="identifier_2_106" class="footnote-link footnote-identifier-link" title="Mercury concentrations in the human brain and kidneys in relation to exposure from dental amalgam fillings">3</a></sup>  Hahn <em>et al </em>(1989) found mercury vapor is released into the mouth by chewing action, and activities that increase this activity such as chewing gum and brushing teeth increase the level of mercury released.  Likely routes of uptakes of released vapors suggested in this study include inhalation, swallowing, and absorption through bone, tooth, and gum tissues in the mouth.  However, the actual amount of mercury absorbed into body tissue was undetermined, and the authors suggest more research is required to determine this.  <sup><a href="http://justthescience.com/archives/106#footnote_3_106" id="identifier_3_106" class="footnote-link footnote-identifier-link" title="Dental &amp;#8220;silver&amp;#8221; tooth fillings: a source of mercury exposure revealed by whole-body image scan and tissue analysis">4</a></sup>  The results of this study suggest that there is an increase in mercury exposure in individuals with amalgam fillings, however,  it is necessary to ascertain both how much mercury is actually absorbed, as well as the effect this mercury has on an individual.</p>
<p>Myriad results have been found in regards to determining the effects of absorbed mercury from amalgam fillings.  Sandborgh-Englund <em>et al</em> (1996)  and Bates (2006) found no evidence of renal toxicity, chronic fatigue syndrome, reproductive, or other chronic diseases  from mercury absorbed from amalgams, but a evidence of susceptibility to Alzheimer&#8217;s, Multiple Sclerosis, and Parkinson&#8217;s from mercury absorbed from amalgams. <sup><a href="http://justthescience.com/archives/106#footnote_4_106" id="identifier_4_106" class="footnote-link footnote-identifier-link" title="No evidence of renal toxicity from amalgam fillings">5</a></sup> <sup><a href="http://justthescience.com/archives/106#footnote_5_106" id="identifier_5_106" class="footnote-link footnote-identifier-link" title="Mercury amalgam dental fillings: an epidemiologic assessment">6</a></sup>  In addition, Grandjean <em>et al</em> (1997) found that individuals treated for self reported amalgam related psychotic disorders responded equally to a mercury purging drug in both treatment and placebo groups, while those in the treatment group actually expelled much higher levels of mercury in their urine.<sup><a href="http://justthescience.com/archives/106#footnote_6_106" id="identifier_6_106" class="footnote-link footnote-identifier-link" title="Placebo Response in Environmental Disease: Chelation Therapy of Patients With Symptoms Attributed to Amalgam Fillings">7</a></sup>  Further study is required for a more definitive answer to whether or not amalgam fillings should be considered a health threat, however, the aforementioned studies have demonstrated that chronic physiological disorders are not associated with amalgams while neurological disorders can be.</p>
<ol class="footnotes"><li id="footnote_0_106" class="footnote"><a href="http://www.fasebj.org/cgi/content/abstract/3/14/2641"><span style="color: #001ee6; text-decoration: underline;">Dental &#8220;silver&#8221; tooth fillings: a source of mercury exposure revealed by whole-body image scan and tissue analysis</span></a></li><li id="footnote_1_106" class="footnote"><a href="http://cat.inist.fr/?aModele=afficheN&amp;cpsidt=1977630"><span style="color: #001ee6; text-decoration: underline;">Toxicity of mercury</span></a></li><li id="footnote_2_106" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/3481133"><span style="color: #001ee6; text-decoration: underline;">Mercury concentrations in the human brain and kidneys in relation to exposure from dental amalgam fillings</span></a></li><li id="footnote_3_106" class="footnote"><a href="http://www.fasebj.org/cgi/content/abstract/3/14/2641"><span style="color: #001ee6; text-decoration: underline;">Dental &#8220;silver&#8221; tooth fillings: a source of mercury exposure revealed by whole-body image scan and tissue analysis</span></a></li><li id="footnote_4_106" class="footnote"><a href="http://ajpregu.physiology.org/cgi/content/abstract/271/4/R941"><span style="color: #001ee6; text-decoration: underline;">No evidence of renal toxicity from amalgam fillings</span></a></li><li id="footnote_5_106" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/16448848"><span style="color: #001ee6; text-decoration: underline;">Mercury amalgam dental fillings: an epidemiologic assessment</span></a></li><li id="footnote_6_106" class="footnote"><a href="http://journals.lww.com/joem/pages/articleviewer.aspx?year=1997&amp;issue=08000&amp;article=00004&amp;type=abstract"><span style="color: #001ee6; text-decoration: underline;">Placebo Response in Environmental Disease: Chelation Therapy of Patients With Symptoms Attributed to Amalgam Fillings</span></a></li></ol>]]></content:encoded>
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		<title>Are antiperspirants dangerous?</title>
		<link>http://justthescience.com/archives/15</link>
		<comments>http://justthescience.com/archives/15#comments</comments>
		<pubDate>Tue, 29 Sep 2009 20:57:52 +0000</pubDate>
		<dc:creator></dc:creator>
				<category><![CDATA[Personal Health]]></category>
		<category><![CDATA[AlCl3]]></category>
		<category><![CDATA[aluminum]]></category>
		<category><![CDATA[aluminum chloride]]></category>
		<category><![CDATA[antiperspirant]]></category>
		<category><![CDATA[health problems]]></category>
		<category><![CDATA[physiological functions]]></category>
		<category><![CDATA[renal failure]]></category>
		<category><![CDATA[sweat]]></category>
		<category><![CDATA[Toxicity]]></category>

		<guid isPermaLink="false">http://justthescience.com/?p=15</guid>
		<description><![CDATA[The issue in question is whether there are ingredients in antiperspirants that will cause detrimental health effects with daily exposure.  The main ingredient that has raised such issues is aluminum chloride (AlCl 3) and its permutations, which is used in some, but not all, products to inhibit perspiration.  Studies by  Hosovski et al (1990) found a [...]]]></description>
			<content:encoded><![CDATA[<p><!-- 		@page { margin: 0.79in } 		P { margin-bottom: 0.08in } -->The issue in question is whether there are ingredients in antiperspirants that will cause detrimental health effects with daily exposure.  The main ingredient that has raised such issues is aluminum chloride (AlCl 3) and its permutations, which is used in some, but not all, products to inhibit perspiration.  Studies by  Hosovski <em>et al </em>(1990) found a significant correlation between aluminum exposure and impaired psycho motor and intellectual abilities<sup><a href="http://justthescience.com/archives/15#footnote_0_15" id="identifier_0_15" class="footnote-link footnote-identifier-link" title="Mental Abilities of Workers Exposed to Aluminium">1</a></sup>.  However, subjects in this study were exposed to continuous high levels of aluminum dust in the their environment from an aluminum foundry; clearly exceeding the daily intake of aluminum one would receive from regular antiperspirant usage.  Recent studies by Lindsay <em>et al </em>(2002) and<em> </em>Graves <em>et al </em>(1990)<em> </em>found no causal link between aluminum exposure vis-a-vi regular use of antiperspirants and Alzheimer’s<sup><a href="http://justthescience.com/archives/15#footnote_1_15" id="identifier_1_15" class="footnote-link footnote-identifier-link" title="Risk Factors for Alzheimer&amp;#8217;s Disease: A Prospective Analysis from the Canadian Study of Health and Aging">2</a></sup> <sup><a href="http://justthescience.com/archives/15#footnote_2_15" id="identifier_2_15" class="footnote-link footnote-identifier-link" title="The association between aluminum-containing products and Alzheimer&amp;#8217;s disease">3</a></sup>.  Any aluminum absorbed into one&#8217;s body is regularly eliminated through normal physiological functions regardless of intake level<sup><a href="http://justthescience.com/archives/15#footnote_3_15" id="identifier_3_15" class="footnote-link footnote-identifier-link" title="Excretion and retention of low or moderate levels of aluminium by human subjects">4</a></sup> (Greger and Baier 1983), but daily exposure to high levels of aluminum (like those found in an aluminum foundry) can have detrimental effects to the body before all traces can be completely eliminated.  When a person&#8217;s physiological functions that aid in the processes of eliminating aluminum from their body are impaired (i.e. renal failure), there is a greater case for limiting your use of AlCl3 based antiperspirants.</p>
<p>It is important to note that the dermatological application of AlCl3 based antiperspirants is immaterial in comparison to the aluminum levels consumed in food. Humans ingest an average of 2-25 mg of aluminum per day from our diet<sup><a href="http://justthescience.com/archives/15#footnote_4_15" id="identifier_4_15" class="footnote-link footnote-identifier-link" title="Aluminum Metabolism">5</a></sup> (Greger 1993) and by using antiperspirants containing AlCl 3, an individual would experience a 2.5% increase in daily aluminum intake, which has been found to be statistically insignificant<sup><a href="http://justthescience.com/archives/15#footnote_5_15" id="identifier_5_15" class="footnote-link footnote-identifier-link" title="A preliminary study of the dermal absorption of aluminium from antiperspirants using aluminium-26">6</a></sup> (Flarend <em>et al</em> 2001).  Based on these studies, it is reasonable to state that while aluminum can be considered toxic in mass quantities (i.e. through industrial exposure), normal use of AlCl 3 based antiperspirants per manufacturers guidelines will not cause aluminum accumulation to the point of significantly increased physical or mental risk, provided that the individual possesses the normal physiological capabilities of processing and eliminating accumulated aluminum.</p>
<ol class="footnotes"><li id="footnote_0_15" class="footnote"><a href="http://md1.csa.com/partners/viewrecord.php?requester=gs&amp;collection=TRD&amp;recid=199204E30017AI" target="_blank"><strong><span style="font-weight: normal;">Mental Abilities of Workers Exposed to Aluminium</span></strong></a></li><li id="footnote_1_15" class="footnote"><a href="http://aje.oxfordjournals.org/cgi/content/abstract/156/5/445" target="_blank">Risk Factors for Alzheimer&#8217;s Disease: A Prospective Analysis from the Canadian Study of Health and Aging</a></li><li id="footnote_2_15" class="footnote"><a href="http://md1.csa.com/partners/viewrecord.php?requester=gs&amp;collection=ENV&amp;recid=2226464" target="_blank">The association between aluminum-containing products and Alzheimer&#8217;s disease</a></li><li id="footnote_3_15" class="footnote"><a href="http://www.ncbi.nlm.nih.gov/pubmed/6684629" target="_blank">Excretion and retention of low or moderate levels of aluminium by human subjects</a></li><li id="footnote_4_15" class="footnote"><a href="http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.nu.13.070193.000355" target="_blank">Aluminum Metabolism</a></li><li id="footnote_5_15" class="footnote"><a href="http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6T6P-42M1CN5-9&amp;_user=10&amp;_rdoc=1&amp;_fmt=&amp;_orig=search&amp;_sort=d&amp;_docanchor=&amp;view=c&amp;_acct=C000050221&amp;_version=1&amp;_urlVersion=0&amp;_userid=10&amp;md5=4c2e72f5278c709a8313bf15fa7767be" target="_blank">A preliminary study of the dermal absorption of aluminium from antiperspirants using aluminium-26</a></li></ol>]]></content:encoded>
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